摘要
目的:探讨Calcyclin在良性前列腺增生、前列腺上皮内瘤变和前列腺癌诊断中的意义。方法:收集90例前列腺不同病变的常规石蜡标本,HE光镜下观察,应用免疫组织化学方法,观察Calcyclin的表达并分析各组间关系。结果:良性前列腺增生28/30例为阳性或强阳性连续性表达,前列腺上皮内瘤变24/28例为弱阳性非连续性表达,前列腺癌30/32例为阴性表达。3组间差异均有统计学意义(χ2=27.36、23.33、36.23,P<0.05)。结论:Calcyclin是前列腺癌敏感而特异性的标记物,有助于前列腺癌的诊断。
Objective：To explore the diagnostic sigificance of Calcyclin in the benign prostanc hyperplasla （BPH）, prostatic intraepithelial neoplasia （PIN）and prostatic cancer. Methods： 90 specimens with different prostate lesions were collected, and reclassified. Immunohistochemical staining for Calcyclin was performed. Re- sults： 28/30 BPH cases were eontinous positive expression of Calcyclin, 24/28 PIN cases were non- continous positive expression, 30/32 prostatic cancer cases were negative expression. There was significant difference a- mong three groups（x2 = 27.36,23.33,36.23, P 〈 0.05）. Continous： Calcyclin was a sensitive and specific mark- er prostate cancer, detection of Calcyclin was contributed to improve pathological diagnosis accuracy of prostatic cancer.
出处
《内蒙古医学杂志》
2013年第3期286-288,共3页
Inner Mongolia Medical Journal
