肠癌康复汤抗HCC细胞实验性肝转移的研究

STUDY ON THE EXPERIMENTAL LIVER METASTASIS FROM HCC CELL PREVENTED WITH CHANG AIKANG FU DECOCTION

采取脾脏植入法成功地建立了ＨＣＣ细胞实验性肝转移模型，将造模后２８只裸鼠随机分为中药组、化 疗组、中化组与对照组。中药组灌服肠癌康复汤，化疗组予５－ＦＵ与ＭＭＣ腹腔或鼠尾静脉注射，中化组在灌服 肠癌康复汤的同时，结合５－ＦＵ与ＭＭＣ腹腔或鼠尾静脉注射，对照组仅以生理盐水灌胃，以各组裸鼠一般生存 状态、血清ＣＥＡ含量、裸鼠肝转移率与肝转移程度为观察指标。结果显示，肠癌康复汤可延长荷瘤裸鼠的生存 期，改善在活状态，配合化疗可显著降低裸鼠血清 ＣＥＡ水平，抑制 ＨＣＣ细胞实验性肝转移的发生率与转移程 度。

A model of experimental liver metastasis form HCC cell was successfully established with spleen inserted in a bald mouse. 28 mice were randomly assigned to four groups, the Chinese medical herb group,the chemothderapy group, the Chinese medical herb combined with chemother- apy group and the control group. The medical herb decoction(Changaikangfu decoction) was given to the Chinese medical group. 5- Fu and MMC were injected to celiaca of mouse or to its tail intravenously in the chemotherapy group. The decoction and chemotherapy were given to the Chiese medical herb combined with chemotherapy group The control group was given to stomach infusion with physiological saline. The sur- vival state,the content of CEA in serum and the morbidity and extent of liver metastasis were observed. It was found that the Chinese medical herb decoction combined with chemotherapy could increase the survial time of mouse with HCC cell, improve its survival state, decrease the content of CEA in serum and inhibit the morbidty and extent of experimental liver metastasis from HCC cell.