参草通脉颗粒三七总皂苷提取工艺优化研究

Study on Extraction Process of Total Saponins of Panax notognsengfrom Shencao Tongmai Granule

目的:为了更好地控制参草通脉颗粒的质量,对其主要药味三七中的三七总皂苷优化提取工艺,为该制剂的质量控制提供科学依据。方法:采用正交试验法,以三七总皂苷的提取量及浸膏得率为考察指标,优选回流法提取三七总皂苷的最佳工艺条件。结果:三七总皂苷的最佳提取工艺为以8倍量70%乙醇回流提取4次,每次1.5h。结论:优选的提取工艺设计合理、简便易行,三七总皂苷提取率高。

Objective： To develo Pquality control method of Shencao Tongmai Granule. Explore the best conditions of extract total saponins from Panax notognseng by ethanol. Methods： Examined total saponins of Panax notognseng and Yield of extract by orthogonal design to optimize refluxing method. Results： The optimal extraction process was refluxing four times with 8 times the amount of 70% alcohol, 1.5 hours each time. Conclusion： Optimization extraction process design is reasonable and available, extraction rate of Tanshinone is higher.