顺尔宁联合喘可治佐治小儿毛细支气管炎的临床疗效观察

Observation on the Clinical Efficacy of Montelukast plus Chuankezhi in Adjunctive Treatment of Child Bronchiolitis

目的:观察顺尔宁联合喘可治佐治小儿毛细支气管炎的临床疗效及其安全性。方法:选取2010年9月～2012年3月在我院儿科住院的70例毛细支气管炎患儿作为观察对象,按入院先后顺序随机分为治疗组和对照组,每组35例。两组均常规给予抗感染、解痉平喘、吸氧、镇静等综合治疗,治疗组在常规治疗的基础上加顺尔宁(孟鲁司特钠咀嚼片)口服,每天4 mg,每晚1次,以及喘可治注射液口服,每次半支,2次/日。治疗7天后观察和比较两组患儿的临床疗效,并对所有病例门诊随访3个月,观察各组患儿在此期间喘息再次发作的情况。结果:治疗7天后,治疗组的总有效率为97.1%,对照组的有效率为80.0%,两组间有显著性差异(X2=7.83,P<0.05)。治疗组症状体征平均持续时间均较对照组明显缩短,差异有统计学意义(P<0.05)。随访3个月内治疗组喘息反复发作的平均次数显著低于对照组,差异有统计学意义(P<0.05)。两组均未见严重不良反应。结论:顺尔宁联合喘可治佐治毛细支气管炎临床疗效显著,并能缩短住院时间,由于顺尔宁可控制毛细支气管炎后的气道慢性炎症,喘可治注射液可增强呼吸道抵抗能力、减少呼吸道反复感染,对毛细支气管炎后喘息的反复发作有预防作用。

Objective： To explore the clinical efficacy and safety of montelukast plus chuankezhi in adjunctive treatment of child bronchiolitis.Methods： 70 cases of child bronchiolitis who were treated in pediatrics department of our hospital from September 2010 to March 2012 were randomly divided into treatment group（n=35） and control group（n=35） according to the order of admission.All the patients were given comprehensive treatment including fight infection,smoothing asthma spasm,oxygen,calm,the treatment group was treated with montelukast orally,4 mg per day,1 time per night,as well as chuankezhi injection orally,half each time,bid.After treatment for 7 days,the clinical efficacy was observed and compared,and all the cases of outpatient were followed-up for 3 months,the recurrence of wheeze was observed during the period.Results： After treatment for 7 days,the total effective rates in treatment group and control group were respectively 97.1% and 80.0%,which was statistically higher in treatment group（X2=7.83,P0.05）.The average continuance time of symptoms and signs in treatment groups was significant lower than those in control group（P0.05）.The recurrence number in treatment group was significantly lower than that in control group during the follow-up（P0.05）.There was no severe complications occurred in the two groups.Conclusions： Montelukast combined with chuankezhi for the adjuvant treatment of child bronchiolitis can significantly improve the clinical symptoms,shorten the hospital stays.Because montelukast can control chronic airway inflammation caused by capillary bronchitis,and chuankezh can strengthen respiratory resistance ability and reduce the respiratory tract infection repeatedly,so it is effective for preventing the the recurrent asthma attack after bronchiolitis.