MicroRNA与非小细胞肺癌关系的研究进展

The Research Progess of the Relationship between MicroRNA and Non-Small Cell Lung Cancer(NSCLC)

肺癌是全世界因肿瘤导致死亡的主要原因,虽然肺癌发生的分子机制在基因和蛋白水平上已经得到部分阐明,但死亡率并没有明显改善。microRNA(miRNA)是一类小分子内源性非编码蛋白的RNA,通过与靶mRNA 3'非翻译区(3'-untranslated region,3'-UTR)序列互补配对,产生翻译抑制或者导致RNA的降解来负性调控基因的表达。近来的研究发现有多种miRNA参与肺癌的发生,发展及转移过程,使其可作为生物标志物用于肺癌早期诊断,靶向治疗及预后监测,为肺癌的诊断和治疗提供新的方向。本文就miRNA在肺癌诊断、分型和治疗中的作用进行综述。

Lung cancer is the leading cause of death from cancer worldwide.Although the molecular network of lung carcinogenesis has been partly known at the levels of genes and proteins,the high mortality is not markedly changed.MiRNAs is a class of short endogenous non-coding RNAs,acting as post-transcriptional regulators for target gene expression by binding to partially complementary 3＇untranslated regions of target mRNAs.Recent research has found a variety of miRNAs involved in lung cancer,including development and metastasis process,so that it can be used as biomarkers for early diagnosis,targeted therapy and clinical prognosis,which provides a new direction for diagnosis and treatment.This review focuses on the function of miRNAs in the diagnosis,prognosis and therapy of lung cancer.