摘要
目的观察老年肺结核患者细胞免疫及体液免疫功能的变化探讨其意义。方法对2010年4月至2012年12月福建医科大学附属泉州第一医院住院或门诊的127例肺结核患者,按年龄分为老年组及青壮年组,50例健康志愿者(健康组)作为对照组,采用流式细胞术检测肺结核患者CD4+T细胞、CD8+T细胞、天然杀伤细胞(NK细胞),采用免疫透射比浊法测定免疫球蛋白。结果①老年人肺结核组CD4+T细胞及CD4/CD8比值与青壮年组及健康组差异具有统计学意义,且低于青壮年组。老年人肺结核组CD8+T细胞与青壮年组及健康组差异具有统计学意义,且高于青壮年组,老年人肺结核组NK细胞与青壮年组差异无统计学意义。②老年肺结核患者血清中IgA,IgG,IgM与青壮年组之间差异无统计学意义。结论老年肺结核患者细胞免疫功能较青壮年低下,但是体液免疫不受影响。
Objective To study the changes in cellular immunity and humoral immunity in elderly tuberculosis patients and their implications.Methods Determined the level of the CD4 cells,CD8 cells,NK cells,B cells with low cytometry in elderly tuberculosis patients and young adult tuberculosis patients,then determine the immunoglobulin with the nephelometric assay.Then comparison with each other.Results ①The percentages of CD4 cells and CD4/CD8 ratio were significantly lower in elderly tuberculosis patients.and The percentages of CD8 cells was significantly higher in elderly tuberculosis patients..②The levels of IgA,IgG,IgM in tuberculosis patients were no obvious differences in the two groups.Conclusion Cellular immunity in elderly tuberculosis patients were lower status than young adult tuberculosis patients but humoral immunity were not influenced.
出处
《中国实用医药》
2013年第13期51-52,共2页
China Practical Medicine
基金
福建省泉州市科技计划重点项目(项目编号:2010Z12)
