血清PCT、sTREM-1及乳酸测定在重症肺炎中的临床意义

Clinical value research of serum PCT,sTERM-1 and lactic acid for patients with severe pneumonia

目的探讨血清降钙素原(PCT)、人可溶性髓系细胞触发受体-1(sTREM-1)和乳酸水平在重症肺炎中的临床测定意义,为重症肺炎的诊断和判断预后提供参考。方法选取2012年4月至2013年1月年本院收治的88例重症肺炎患者,在入院后的第1、4、7天分别进行PCT、sTREM-1和乳酸水平的检测,根据预后将88例重症患者分为死亡组和存活组来进行比较和分析。结果 88例患者中死亡25例,存活63例。死亡组第4、7天的PCT值、sTREM-1值和乳酸值分别为明显高于存活组,差异具有统计学意义(P<0.05)。结论动态监测血清中的PCT、sTREM-1和乳酸的水平有助于判定重症肺炎的病情程度和预后,可应用于临床。

Objective To explore the clinical value for judging the condition and prognostic of patients with severe pneumonia by dynamic monitoring of procalcitonin（PCT）,human soluble myeloid cells triggering receptor-1（sTREM-1） and lactate levels in serum.Methods 88 cases of patients with severe pneumonia received in our hospital from April 2012 to February 2013 was monitored with PCT,sTREM-1 and lactate levels on 1th,4th,7th days after admission,the 88 cases of patients were divided into the death group and survival group for further compare and analysis according to the prognosis.Results 25 patients died,63 patients survived in 88 cases.The levels of PCT,sTREM-1 and lactate in serum on the 4th and 7th day in death group were significantly higher than the survival group,the difference was statistically significant（P0.05）.Conclusion Dynamic detection of PCT,sTREM-1 and lactate levels trend in serum was helpful for the prognosis of patients with severe pneumonia.