摘要
收集临床石蜡包埋的乳腺癌病例和乳腺良性病例共116例,使用原位分子杂交法检测乳腺癌和乳腺良性病变组织中miR-340的表达,分析其与乳腺癌临床病理特征和患者预后的关系。结果显示乳腺癌组织中miR-340表达较良性病变组织显著下降(P<0.05),并且miR-340表达与乳腺癌淋巴结转移、肿瘤组织学分级和临床分期均呈负相关(P<0.05),miR-340阳性表达的乳腺癌患者总生存期显著高于阴性表达患者(P<0.05)。miR-340在乳腺癌发生和发展过程中可能发挥了重要作用,是乳腺癌侵袭和转移的潜在生物学标志物。
The expression of miR-340 was analyzed by in situ hybridization on 116 cases of paraffin embedding breast cancer and benign diease tissue specimens. Clinical and prognostic significance was investigated on the expression of miR-340 in patients with breast cancer. Altered expression of miR-340 was observed in archival breast cancer specimens, compared with benign breast disease specimens. And down-regulated expression of miR-340 was individually associated with lymph node metastasis, high clinical stage, and poor survival of breast cancer patients. miR-340 may play important roles in breast cancer progression, suggesting that miR-340 should be further evaluated as a novel biomarker for breast cancer metastasis and prognosis, and potentially a therapeutic target.
出处
《安徽医科大学学报》
CAS
北大核心
2013年第6期708-710,共3页
Acta Universitatis Medicinalis Anhui
基金
国家自然科学基金(编号:81101597)
