非小细胞肺癌患者血清bFGF和MMP-9检测的临床意义

Clinical Significance of Serum Expression of MMP-9 and bFGF in Non-small Cell Lung Cancer

目的研究基质金属蛋白酶-9(MMP-9)和碱性成纤维细胞生长因子(bFGF)在非小细胞肺癌患者和健康者的血清样本中的含量及其与肿瘤分化程度、临床分期、远处转移等病理特征的相关性。方法通过酶联免疫吸附法(ELISA)分别检测非小细胞肺癌患者和正常对照者的血清样本中的MMP-9、bFGF的浓度,并进行统计学分析。结果 MMP-9和bFGF在非小细胞肺癌患者血清中的含量明显高于健康人群(P<0.01),并与肿瘤分期、肿瘤大小、远处转移呈正相关(P<0.05),与分化程度呈负相关(P<0.05);而与年龄、性别、肿瘤的病理类型无关(P>0.05),经Pearson相关性检验发现两者之间显著相关(r=0.807,P<0.01)。结论 MMP-9和bFGF共同参与非小细胞肺癌的发生发展、侵袭转移过程,联合检测可作为临床监测病情发展的指标。

Objective To investigate the serum expression of matrix metalloproteinase-9 （MMP-9） and basic fibroblast growth factor （bFGF） in patients with non-small cell lung cancer （NSCLC） and ealthy people, as well as its relationship with clinical pathological features such as tumor differentiation, clinical stage, distant metastasis,etc. Methods The serum expression of MMP-9 and bFGF in NSCLC and healthy people were measured by ELISA and processed by statistics. Results The serum expression of MMP-9 and bFGF in NSCLC were significantly higher than that in healthy people （P〈0.01）, and the levels of MMP-9 and bFGF were significantly different among different stage tumor size, metastasis status,and the degree of differentiation （all P〈0.05）. However, there were no significant difference among different age, gender, smoking history, tumor pathological type（all P〉0.05）. Moreover, under person test, the serum of MMP-9 was found to be significantly associated with that of bFGF （r=0.807,P〈0.01）. Conclusion MMP-9 and bFGF may take part in the progress of lung cancer, and can be used as clinical monitoring of disease indicators.