白蛉病毒属研究进展

Recent Advance in Phlebovirus

白蛉病毒属病毒是单股负链RNA病毒,隶属布尼亚病毒科,基因组分为L、M和S三个片段,分别编码RNA依赖的RNA聚合酶、包膜糖蛋白和核蛋白。白蛉病毒是虫媒病毒,主要通过节肢动物传播,迄今为止,文献报道的白蛉病毒已有70多种,68个已知病毒种被分为白蛉热病毒组和乌库病毒组,其中某些白蛉热病毒组成员与人类疾病密切相关,而且最近又有新型白蛉病毒出现,本文就白蛉病毒属的分子特征、流行病学、诊断、治疗及新发现的白蛉病毒的概况展开综述。

Genus Phlebovirus is single negative-strand RNA virus, and belongs to family bunyaviridae. Its genomes have three segments including L, M and S encoding RNA-dependent RNA polymerase, envelope glycoprotein and nucleoprotein respectively. Phlebovirus is arbovirus and can be disseminated by arthro- pod. More than 70 types of Phlebovirus so far have been reported, and 68 known serotypes are divided into groups Sandfly fever and Uukuniemi, of which a few members are closely related to human diseases. In ad- dition, new emerging viruses of genus Phlebovirus are discovered recently. In this review, the latest research progress in molecular characteristics, epidemiology, diagnosis, treatment and emerging viruses of Phlebovirus is summarized