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反复七天给予甲基安非它明减少大鼠海马去甲肾上腺素的释放

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摘要 目的研究反复给予甲基安非它明对大鼠蓝斑至海马投射纤维去甲肾上腺素类神经递质释放的影响。方法甲基安非它明组大鼠给予小剂量甲基安非它明(5mg/kg,腹腔注射,qd,持续7 d),对照组大鼠等量生理盐水处理7 d,停药1 d后,电刺激麻醉大鼠蓝斑核团,碳纤维电极恒流安培法实时记录海马CA1区递质释放。结果与对照组相比,甲基安非它明组大鼠体重下降,刻板行为评分增加;电刺激蓝斑核团,海马CA1区递质释放信号的达峰时间延长(2.1±0.5 s vs 1.4±0.2 s,n=6,P<0.05),峰值下降(134.3±79.1 pA vs 328.7±130.7 pA,n=6,P<0.05),半衰时间减少(5.9±1.6 s vs 10.3±4.1 s,n=6,P<0.05),致使海马区域释放的递质减少。结论 7 d给予甲基安非它明减少了蓝斑至海马投射区域递质的释放,可能与甲基安非它明神经毒性作用机制有关。
作者 王峰 黄宏平 陈洁 汪萌芽
机构地区 皖南医学院法医毒理和毒化教研室 皖南医学院细胞电生理研究室
出处 《毒理学杂志》 CAS CSCD 北大核心 2013年第2期140-142,共3页 Journal of Toxicology
基金 第四批安徽省优秀青年科技基金资助项目(08040106817)
关键词 甲基安非它明 电刺激 碳纤维电极 去甲肾上腺素
分类号 R992 [医药卫生—毒理学]
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参考文献12

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毒理学杂志
2013年 第2期

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