期刊文献+

他汀类药物在肺动脉高压动物模型中的机制研究进展 被引量:2

原文传递
导出
摘要 肺动脉高压是以小肺动脉闭塞性重构为特征的疾病,肺血管阻力进行性增加,进而右心室肥厚扩张的一类恶性心脏血管疾病。近年来在动物实验研究发现他汀类药物对于肺动脉高压有治疗作用。其主要机制包括:一氧化氮通路、内皮素-1通路、增加前列腺素产生、对平滑肌细胞作用、抗炎、遗传学等机制。现对他汀类药物在肺动脉高压动物模型的研究机制作简要论述。
出处 《中国临床药学杂志》 CAS 2013年第3期192-196,共5页 Chinese Journal of Clinical Pharmacy
  • 相关文献

参考文献4

二级参考文献40

  • 1Bellisarii FL, Gallina S, De Caterina R. Tumor nercosis factor- alpha and cardiovascular diseases. Ital Heart J, 2001, 2: 408- 417.
  • 2Nishimura T, Vsazar LT, Faul JL, et al. Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells. Circulation, 2003, 108 : 1640- 1645.
  • 3Nishimura T, Faul JL, Berry GJ, et al. Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats. Am J Respir Crit Care Med, 2002, 166:1403-1408.
  • 4] Murata T, Sato K, Hori M, et al. Decreased endothelial nitricoxide synthase(eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension. J Biol Chem, 2002, 277: 44085-44092.
  • 5Murata T, Kinoshita K, Hori M, et al. Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vase Biol, 2005, 25 : 2335- 2342.
  • 6Girgis RE, Li D, Zhan X, et al. Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Heart Circ Physiol, 2003, 285 : H938-945.
  • 7Tuder RM, Groves B, Badesch DB, et al. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol, 1994, 144:275- 285.
  • 8Dorfmtiller P, Perros F, Balabaniam K, et al. Inflammation in pulmonary arterial hypertension. Eur Respir J, 2003, 22 : 358- 363.
  • 9Kinlay S. Potential vascular benefits of statins. Am J Med, 2005, 118(Suppl 12A) : 62-67.
  • 10Sparrow CP, Burton CA, Hernandez M, et al. Simvastatin has anti-imflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering. Arterioscler Thromb Vasc Biol, 2001, 21:115-121.

共引文献35

同被引文献23

  • 1邱川,李明才,武燕,李敏.慢性阻塞性肺疾病气道炎症的研究进展[J].中国呼吸与危重监护杂志,2011,10(2):196-199. 被引量:58
  • 2慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中国医学前沿杂志(电子版),2014,6(2):67-80. 被引量:2026
  • 3Thirapatarapong W, Armstrong H F, Barrels M N. Exercise capacity and ventilatory response during exercise in COPD patients with and without β blockade[ J] .Lung, 2013, 191 (5) : 531-536.
  • 4Brun H, Holmstrm H, Thaulow E, et al. Patients with pul- monary hypertension related to congenital systemic to pul- monary shunts are characterized by inflammation involving endothelial cell activation and platelet mediated inflamma- tion[ J].Congenital Heart Disease, 2009, 4(3) : 153-159.
  • 5Wynants M, Quarck R, Ronisz A, et al. Effects of C-reac- tive protein on human pulmonary vascular cells in chronic thromboembolic pulmonary hypertension [ J ], European Respiratory Journal, 2012, 40(4): 886-894.
  • 6JieLi,Jian‐JunLi,Jian‐GuoHe,Jing‐longNan,Yuan‐linGuo,Chang‐mingXiong.Atorvastatin Decreases C‐Reactive Protein‐Induced Inflammatory Response in Pulmonary Artery Smooth Muscle Cells by Inhibiting Nuclear Factor‐κB Pathway[J]. Cardiovascular Therapeutics . 2010 (1)
  • 7ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories.ATS statement:guidelines for the six-minute walk test. American Journal of Respiratory and Critical Care Medicine . 2002
  • 8Young RP,Hopkins RJ.Update on the potential role of statins in chronic obstructive pulmonary disesase and its co-morbidities. Expert Rev Respir Med . 2014
  • 9张郁青,张秀伟,朱颖,杨健.阿托伐他汀对慢性阻塞性肺疾病合并肺动脉高压患者的影响[J].心肺血管病杂志,2009,28(4):250-252. 被引量:18
  • 10王生浩,刘双.肺动脉高压药物联合治疗的进展[J].心肺血管病杂志,2012,31(1):92-94. 被引量:19

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部