EGFR在局部晚期口腔鳞癌中的表达及与TPF诱导化疗的关系

Expression of EGFR in locally advanced oral squamous carcinoma and its relationship with TPF induction chemotherapy

目的:探讨EGFR在晚期口腔鳞癌患者中的表达及与TPF诱导化疗的关系。方法:以256例局部晚期口腔鳞癌的前瞻性临床随机对照试验患者为研究对象,采用免疫组织化学方法,检测口腔鳞癌治疗前组织中EGFR的表达情况,分析其与临床病理各项指标的关系。采用SPSS 18.0软件包对数据进行统计学分析。结果:EGFR阳性表达强度与患者的年龄显著相关(P=0.015),未发现其与患者其他临床病理指标之间的显著相关性;在病理和临床疗效方面,EGFR阳性表达强度与TPF诱导化疗疗效无显著相关性。EGFR表达与口腔鳞癌患者的预后无显著相关,包括肿瘤复发、总体生存率、无瘤生存率、无肿瘤复发生存率和无肿瘤转移率。结论:EGFR的表达强度与患者的年龄相关,其在口腔鳞癌中的临床应用价值有待进一步研究。

PURPOSE： To figure out the expression of EGFR in locally advanced oral squamous cell carcinoma and the relationship between EGFR expression and TPF induction chemotherapy. METHODS： Two hundred and fifty-six patients with locally advanced oral squamous cell carcinoma in a prospective randomized controlled trial were included in this study. Using immunohistochemical staining against EGFR, expression of EGFR was detected in the oral squamous cell carcinoma tissues before treatment. The relationship between EGFR expression and elinicopathologic indicators was analyzed as well as the relationship between EGFR expression and TPF induction chemotherapy. Statistical analysis was performed using SPSS18.0 software package. RESULTS： There was a significant correlation between the EGFR positive expression and the age of patients （P=0.015）, younger patients had higher EGFR expression level. No significant correlation between EGFR expression and other elinicopathologie indicators was found. According to the pathological and clinical response to TPF induction chemotherapy, there was no significant correlation between EGFR expression level and the response to TPF induction chemotherapy. The correlation between EGFR expression and the prognosis of oral squamous cell carcinoma patients was not significant as regards to tumor recurrence, overall survival, disease free survival, locoregional recurrence free survival and distant metastasis free survival. CONCLUSIONS： EGFR expression was related to the age of patients with oral squamous cell carcinoma. Further studies are suggested on the clinical application of EGFR expression as target therapy in oral squamous cell carcinoma.