自体血管内皮祖细胞治疗缺血缺氧性脑损伤

Autologous endothelial progenitor cells for treatment of ischemic/hypoxic brain injury

背景:缺血缺氧性脑损伤后的神经再生、神经功能的恢复与缺血部位新生血管的形成和重塑有着密切的关系。血管内皮祖细胞参与出生后缺血组织的血管新生及修复,促使血液循环再通和氧气等营养物质的供应,为神经功能的恢复提供微环境。目的:探讨自体血管内皮祖细胞治疗缺血缺氧性脑损伤的可行性、有效性及安全性,探索改善脑损伤患者神经功能修复的新方法。方法:应用计算机检索PubMed、ScienceDirect、Springerlink、CNKI、万方等数据库近10年的相关文献。英文关键词为"EPCs、endothelial progenitor cell、stroke"等,中文关键词为"内皮祖细胞、干细胞移植、脑卒中"等,选择内容与血管内皮祖细胞治疗缺血缺氧性疾病相关的文献,同一领域文献则选近期发表的或发表在权威杂志上的文章,共纳入43篇参考文献。结果与结论:脑缺血后神经再生、神经功能的恢复与缺血部位新生血管的形成和重塑有着密切的关系,内皮祖细胞参与出生后缺血组织的血管发生及修复,促进血液循环及氧气等营养物质的供应,为神经功能的恢复提供微环境。自体血管内皮祖细胞治疗缺血缺氧性脑损伤是可行的、安全的、有效的,但仍需大量的生物学及动物实验为其临床应用提供客观的理论依据。

BACKGROUND： Following ischemic/hypoxic brain injury, neurogenesis and neurofunctional recovery are closely related to vascular formation and plasticity in ischemic region. Vascular endothelial progenitor cells participate in vascular formation and repair in postnatal ischemic tissue, promote the recanalization of blood flow and the supply of nutritive substances such as oxygen, providing microenvironment for neurofunctional recovery. OBJECTIVE： To evaluate the feasibility, efficacy and safety of use of autologous vascular endothelial progenitor cells in the treatment of ischemic/hypoxic brain injury and investigate a new method for improving the neurological function of patients with ischemic/hypoxic brain injury. METHODS： A computer-based online retrieval of PubMed, ScienceDirect, Springerlink and CNKI databases was performed for papers describing use of vascular endothelial progenitor cells in the treatment of ischemic/hypoxic brain injury using the key words ＂EPCs, endothelial progenitor cell, stroke＂ in English and Chinese. In the same research filed, papers that published recently or in high impact factor journals were selected. A total of 43 papers were suitable for final analysis. RESULTS AND CONCLUSION： Following ischemic/hypoxic brain injury, neurogenesis and neurofunctional recovery are closely related to vascular formation and plasticity in ischemic region. Vascular endothelial progenitor cells participate in vascular formation and repair in postnatal ischemic tissue, promote the recanalization of blood flow and the supply of nutritive substances such as oxygen, providing microenvironment for neurofunctional recovery. The use of autologous vascular endothelial progenitor cells in the treatment of ischemic/hypoxic brain injury is feasible, safe and effective. Nevertheless, a larger number of biological and animal experiments are needed for providing theoretical evidence for clinical application of autologous vascular endothelial progenitor cells.