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耶尔森菌Ⅲ型分泌系统研究进展 被引量:3

Function and Regulation of Type Ⅲ Secretion System in Yersinia Species
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摘要 Ⅲ型分泌系统是目前细菌中已知的最为复杂的分泌系统,也是致病性耶尔森菌包括鼠疫耶尔森菌、小肠结肠炎耶尔森菌和假结核耶尔森菌所共有的重要致病策略之一。简要综述了耶尔森菌Ⅲ型分泌系统的遗传构成、分泌装置的结构和组成、效应蛋白分泌及调控、效应蛋白的功能等方面的主要研究成果和研究进展。 Type Ⅲ secretion system(T3SS) is one of the most complicated secretion system in bacteria hitherto. Yersinia T3SS is a common pathogenesis mechanism shared by three human pathogenic Yersinia species, Y.pestis, Y. pseudotuberculosis and Y.enterocolitica. This review focused on the aspects of genetic elements composition of T3SS, structure and the assembly of the injectisome, secretion of effeetors and its tight regulations and the molecular functions of effeetors to present the current understanding of Yersinia T3SS.
出处 《生物技术通讯》 CAS 2013年第3期418-422,共5页 Letters in Biotechnology
基金 国家自然科学基金(30970121 31170122)
关键词 耶尔森菌 Ⅲ型分泌系统 鼠疫 注射小体 Yersinia type Ⅲ secretion system plague injectisome
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