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结核分枝杆菌PE/PPE蛋白研究进展 被引量：2

Progress on PE/PPE proteins of Mycobacterium tuberculosis
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摘要 PE/PPE蛋白是分枝杆菌所独有的蛋白家族,因其氨基端分别含有Pro-Glu(PE)和Pro-Pro-Glu(PPE)的基序而得名,其编码基因约占结核分枝杆菌整个基因组的10%。PE/PPE蛋白从被发现开始就引起了人们的广泛兴趣,本文就近年来的研究进展作一综述。 PE/PPE proteins are named after the conserved proline-glutarnate （PE） or proline proline glutamate （PPE） motifs at their N-terminus. PE/PPE multigene family is unique to Mycobacterium and codes for approximately 10% of the whole genome of Mycobacterium tuberculosis. Since their formal identification, PE/PPE proteins have attracted much interest. This review summarizes the recent knowledge about the gene family in order to better understand its biological, function.
作者 孙林 闵晨雨 钱源 焦新安
机构地区 扬州大学江苏省人兽共患病学重点实验室
出处 《中国人兽共患病学报》 CAS CSCD 北大核心 2013年第5期499-503,共5页 Chinese Journal of Zoonoses
基金 国家重点基础研究发展计划项目(2012CB518800) 江苏省普通高校研究生科研创新计划项目(2010-599)资助~~
关键词 结核分枝杆菌 PE PPE蛋白 Mycobacterium tuberculosis PE/PPE protein
分类号 R378 [医药卫生—病原生物学]
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参考文献20

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同被引文献17

  • 1吴雪琼.结核分枝杆菌保护性抗原的研究进展[J].中华结核和呼吸杂志,2006,29(5):340-342. 被引量：22
  • 2王树志.鹿结核病概述[J].中国人兽共患病杂志,1987,3(6):57-58.
  • 3Griffin J F T, Mackintosh C G. Tuberculosis in deer percep- tions, problems and progress [ J]. The Veterinary Journal, 2000,160:202-219.
  • 4Reginaldo G Bastos, Sibele Borsuk, Fabiana K Seixas, et al. Re- combinant Mycobacterium bovis BCG [ J ]. Vaccine, 2009 ( 27 ) : 6495-6503.
  • 5Sabine Daugelat, Jane Kowall, Jens Mattow, et al. The RD1 pro- teins of Mycobacterium tuberculosis : expression in Mycobacteri- um smegmatis and biochemical characterization [ J ]. Microbes and Infection, 2003,5 : 1082-1095.
  • 6Mukherjee P, Dutta M, Datta P, et al. The RDl-encoded anti- gen Rv3872 of Mycobacterium tuberculosis as a potential candi- date for serodiagnosis of tuberculosis [ J ]. Origiriginal Article, 2007,13 : 146-152.
  • 7Si Guo,Rni Xue,Yi Li,et al. The CFP10/ESAT6 complex of Mycobacterium tuberculosis may function as a regulator of mae- rophage cell death at different stages of tuberculosis infection [J]. Medical Hypotheses,2012,78:389-392.
  • 8Alexander S Pyre, Priseille Bmdin, Roland Bmsch, et al. Loss of RDI contributed to the attenuation of the live tuberculosis vaccines Mycobacterium boris BCG and Mycobaeterium mieroti [ J ]. Molecular Microbiology, 2002,46 ( 3 ) : 709-717.
  • 9Aagaarda C, Govaertsb M, Meiklec V, et al. Detection of bo- vine tuberculosis in herds with different disease prevalence and influence of paratubereulosis infection on PPDB and ES- AT-6/CFP10 specificity[ J]. Preventive Veterinary Medicine, 2010,96:161-169.
  • 10刘晓清.新的结核分枝杆菌RD1基因编码产物介导的T细胞反应在结核感染诊断中的应用[J].中国医学科学院学报,2008,30(3):305-308. 被引量：6

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中国人兽共患病学报
2013年 第5期

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