江苏省一起急性胃肠炎爆发的疫情调查(英文)

Investigation of an acute gastroenteritis outbreak in Jiangsu Province

目的调查和分析一起发生在江苏省常州市某小学急性胃肠炎爆发疫情,明确流行病学特征和基因型特征。方法根据统一设计的流行病学调查表,对病例和对照的饮食、饮水和卫生习惯等情况开展病例对照研究。对病例的排毒情况进行跟踪调查,明确排毒期长短。采集病例和对照的标本,进行荧光定量PCR方法检测,对部分阳性结果标本进行测序以明确基因型。结果 11月22日起出现首例病例,11月22日至12月2日为主要发病阶段。此期共发病269例,其中学生发病264例,罹患率17.4%,教师发病5例,罹患率4.4%,两者存在统计学差异(χ2=13,P<0.01);排毒期调查结果显示,本起暴发疫情最短排毒期为发病后3d,最长为14d,中位时间为7d。共采集172份标本,其中82份检测结果为诺如病毒GII型阳性,未检测到轮状病毒及腺病毒,18份诺如病毒GII型阳性标本测序分析显示均为GII.12基因型。结论结合病例临床特征、流行病学调查及实验室检测结果综合分析,判定本起疫情为诺如病毒GII.12型感染导致的急性胃肠炎爆发疫情,该型别在我省尚为首次发现。爆发原因可能为呕吐物-口引起的大范围传播。

In December 2011, an acute gastroenteritis outbreak affected a primary school in Changzhou City, Jiangsu Province. To understand the characteristics and cause of the disease, the cases were investigated individually based on the standardized epidemiological survey form, the demographic data of cases and the samples were collected at the same time. The nucleic acid of the samples was detected by Real-time RT PCR. Genotype study was conducted by analyzing the nucleotide se- quence of N-S region. Sample from a total of 276 cases of gastroenteritis outbreak from Nov 22 to Dec 13, 2011, involving 264 cases of students （the morbidity was 17.4 %）, 5 teachers （4.4%） and 7 parents, were collected for the investigation. The most anal swab samples were norovirus positive, which belonged to GIL 12 genotype. Results from comprehensive analysis with clinical characteristics, epidemiological investigation, and laboratory test indicated that this epidemic was an acute gastro enteritis outbreak caused by the norovirus GIL. 12 type with a probably transmission pattern of vomit-to-mouth.