云南睾丸生殖细胞肿瘤105例临床特点与疗效评价

Clinical Study on 105 Cases of Testicular Germ Cell Tumors in Yunnan Province

目的分析云南睾丸肿瘤的发病特点、病理类型以及临床治疗效果,结合欧美诊疗指南探讨睾丸肿瘤的规范化治疗与随访.方法回顾性分析云南省肿瘤医院1995年1月至2008年12月收治的105例睾丸生殖细胞肿瘤病例资料,探讨睾丸肿瘤的临床特点与治疗方法.结果本组105例患者年龄分布1～86岁.其中精原细胞瘤71例(67.6%),平均年龄37.9岁;非精原细胞瘤34例(32.4%),平均年龄27.5岁;精原细胞瘤患者死亡14例,总体生存率为80.3%,非精原细胞瘤患者死亡12例,总体生存率为64.7%.结论高危患者的综合治疗、规范治疗尤其是对于化疗后复发的挽救性治疗对于提高患者生存率十分重要.

Objective To study the epidemiology, pathology, combined modality therapy and long term outcome of testicular cancer in Yunnan Province. Method We retrospectively analyzed the data of 105 cases of testicular cancer in our hospital from 1995 to 2007, and the clinical characteristics and treatment methods were investigated. Results The age of 105 patients was from 1 to 86 years old, with a mean age of 34.3. There were 71 cases （64.5%） of seminoma, 34 cases （30.9%） of nonseminoma including 11 cases of embryonal carcinoma, 8 cases of Yolk sac tumor and 16 cases of miscellaneous germ cell tumours. All of the patients were followed up from 16 to 182 months with an average period of 63 months. The overall survival rate in seminoma was 80.3%, and 64.7% in nonseminoma. Conclusion Careful staging at the time of diagnosis, adequate early treatment based on chemotherapy, radiotherapy, surgery and very strict follow up and salvage therapies will improve the long term outcome of testicular cancer.