摘要
目的:检测不同的人工脑脊液灌洗时间对脑外伤后脑水肿的影响。方法:将SD大鼠240只,随机分为假手术组、脑外伤模型组、人工脑脊液灌洗3 h组、6 h组、9 h组,各组又按处死时间即伤后12 h,1 d,3 d,7 d分为4个亚组,通过检测水、Na+、K+含量、VEGF的表达来证实不同灌洗持续时间对减轻外伤后脑水肿的作用。结果:与假手术组、脑外伤模型组相比,人工脑脊液灌洗组脑组织含水量和Na+含量下降,K+含量和VEGF灰度值水平升高,在伤后12 h,1 d,3 d各时间点比较差异均有统计学意义(P<0.05),且随着灌洗时间的延长,差异更加显著。结论:人工脑脊液灌洗能减轻脑外伤后脑水肿的程度,灌洗时间越长,效果越明显。
Objective: To detect the impact of artificial cerebrospinal fluid lavage time on the edema of traumatic brain injury. Methods: A total of 240 SD rats were randomly divided into a sham group, a traumatic brain injury model group, 3 artificial cerebrospinal fluid lavage groups (3 h, 6 h and 9 h). Each group was divided into 4 sub-groups by time of sacrifice namely 12 h, 1 d, 3 d and 7 d postoperatively. We detected the content of brain water, sodium, and potassium, and the VEGF expression to confirm whether the duration oflavage could reduce the traumatic brain edema.
出处
《中南大学学报(医学版)》
CAS
CSCD
北大核心
2013年第5期510-516,共7页
Journal of Central South University :Medical Science
关键词
人工脑脊液
脑外伤
脑水肿
artificial cerebrospinal fluid of traumatic
brain injury
cerebral edema