人类乳头状瘤病毒与鼻内翻性乳头状瘤关系的Meta分析

Meta analysis of the relationship between human papilloma virus and nasal inverted papilloma

目的:探讨人类乳头状瘤病毒(HPV)的感染与鼻内翻性乳头状瘤(NIP)的发生、复发及恶变的关系。方法:选用Pubmed(1990-2011)、Cochrane图书馆、CNKI(1979-2011)、维普(1989-2011)、中国生物医学文献光盘数据库(1990-2011)及万方等数据库全面检索国内外已发表的HPV与NIP相互关系的相关文献,应用RevMan5.0分析软件对各研究原始数据进行统计处理,计算合并OR(odds ratio比值比)及95%CI(confidenceinterval置信区间)。结果:Meta分析结果为HPV与NIP发生的OR为34.44,95%CI为12.96～91.56,复发组OR为3.66,95%CI为1.77～7.56,恶变组OR为1.79,95%CI为0.94～3.40,恶变组高危病毒OR为49.35,95%CI为12.58～193.61,复发组高危病毒OR为1.94,95%CI为0.30～12.58。结论:HPV与NIP发生及复发密切相关,HPV高危病毒与NIP恶变密切相关。

Objective： To evaluate the relationship between human papilloma virus（HPV） infection and the occurrence,recurrence and malignant transformation of nasal inverted papilloma（NIP）.Method： With comprehensive retrieval of related literature that had been published in databases included Pubmed（1990-2011）,Cochrane Library,CNKI（1979-2011）,VIP（1989-2011）,CBM（1990-2011） and WANFANG Meta-analysis software RevMan 5.0 was used to analyze the raw data and to calculate the value of combined odd ratio（OR） and 95% confidence interval（CI）.Result： According to Meta-analysis,the occurrence group between HPV and NIP,the OR was 34.44 and 95%CI was 12.96-91.56;the recurrence group,the OR was 3.66 and 95%CI was 1.77-7.56,to the high-risk HPV,the OR was 1.94 and 95%CI was 0.30-12.58;the malignant transformation group,the OR was 1.79 and 95%CI was 0.94-3.40 to the high-risk HPV,the OR was 49.35 and 95%CI was 0.45-11.23.Conclusion： HPV may play an important role in the occurrence and recurrence of NIP and high-risk HPV was closely related to the progress of NIP.