多囊卵巢综合征患者血清apoB/apoAⅠ比值对代谢综合征的诊断价值

The diagnostic significance of apoB/apoAⅠ for metabolic syndrome in patients with polycystic ovary syndrome

目的探讨多囊卵巢综合征(PCOS)患者apoB/apoAⅠ比值对代谢综合征(MS)的诊断价值。方法收集185例符合2003年鹿特丹诊断标准的PCOS患者,采集病史并对其进行体格测量和性激素、糖脂代谢等各项生化指标测定。结果 MS患病率为19.46%,而至少合并一项MS组分异常的患病率则为56.76%;apoB/apoAⅠ比值与体重指数(BMI)、低密度脂蛋白胆固醇(LDL-C)水平呈正相关,与高密度脂蛋白胆固醇(HDL-C)水平呈负相关,且随着MS组分异常项数的增加而升高;以0.66为截断值时,apoB/apoAⅠ比值对MS的诊断价值较高(敏感度为0.917,特异性为0.700)。结论 PCOS患者的apoB/apoAⅠ对MS有较好的诊断和监测价值。

Objective To analyze the diagnostic significance of apoB/apoA I for metabolic syndrome （MS） in patients with polycystic ovary syndrome （PCOS）. Methods Endocrinic, metabolic and anthropometric parameters were collected from 185 women diagnosed as PCOS based on the 2003 Rotterdam criteria. Results The incidence of MS was 19.46%, and 56.76% of these patients had at least one abnormal component of MS. ApoB/apoA I had a statistically significant positive correlation with BMI and LDL-C, but a negative correlation with HDL-C, and the ratio went up as the number of abnormal MS components increased. There was also a quite good diagnostic value of apoB/apoA I for MS with a threshold value of 0.66, accompanied by a sensitivity of 91.7% and specificity of 70.0%. Conclusion ApoB/apoA I is quite a valuable diagnostic index for MS in patients with PCOS.