慢性阻塞性肺疾病临床表型的研究进展

Research progress in clinical phenotypes of chronic obstructive pulmonary disease

慢性阻塞性肺疾病(COPD)是一种气流受限不完全可逆的疾病,临床通常根据气流受限严重程度指导治疗。然而COPD患者在临床表现、疾病进展、治疗反应、肺功能下降程度及生活质量等方面存在显著差异。目前单一使用FEV1评估气流受限程度将COPD进行分类及作为疾病诊断、评估和治疗的手段,不能更好地反映COPD的异质性。近年来有学者试图通过不同的表型对COPD异质性进行描述和研究,认为COPD表型是未来研究的方向。本文就目前该方面的研究进展作一综述。

Chronic obstructive pulmonary disease （COPD） is a common respiratory disease defined as the presence of incomplete reversible air flow obstruction, and its treatment is mostly guided by the severity of this air flow obstruction. However, the traditional diagnosis, assessment and management of COPD are currently challenged. In recent years, it has widely been recognized that COPD is a complex syndrome characterized by numerous pulmonary and extrapulmonary manifestations. As for a method of diagnosis, evaluation, treatment and categorization of COPD, airflow obstruction alone isn＇t good enough for reflection of the heterogeneity of this disease. Some researchers reached a consensus on COPD, in which the importance of COPD phenotypes for the prevention and control of COPD were stressed. As the clinical phenotypes of COPD are still unclear and become a research focus, we summarized the recent research progress on COPD clinical phenotypes in this review.