TGF-α、IGF-Ⅱ、NPY、NT在慢性肾功能衰竭患者血液透析中的检测及意义

The Detection and Clinical Significance of Changes of Serum TGF -α, IGF - Ⅱ and Plasma NPY. NT Leveis During Hemodialysis in Patients with Chronic Renal Failure

为了探讨慢性肾功能衰竭患者（ＣＲＦ）血液透析过程中ＴＣＦ－α、ＩＧＦ－Ⅱ、ＮＰＹ、ＮＴ的水平及其作用机理，我们采用放射免疫分析技术对４５例维持性血液透析前后的患者进行了上述四项指标检测。结果显示，ＣＲＦ患者在血液透析过程中，透析膜等因素可激活单个核细胞，使产生ＴＣＦ－α和ＩＧＦ－Ⅱ增高，并且患者存在ＮＰＹ与ＮＴ分泌异常，ＮＰＹ、ＮＴ作为体内的重要神经递质，参与了患者疾病及并发高血压的病理生理过程。

Objectlve To study the changes of serum TGF- α. IGF-Ⅱ and plasma NPY.NT levels with the related mechanism during hemodialysis for patients with chronic renal failure (CRF). Methods Levels of the above four items were determined with RIA before and after hemodialysis in 45 patients maintained on chronic dial- ysis. Results Levels of TGF- α and IGF-Ⅱ could increase during the process of dialysis because some factors including the quality of the dialyser membrane might activate the mononuclear cells. Besides, there were abnormal- ities in the secretion of NPY and NT in patients with CRF, with level changes in opposite directions during hemodialysis (NPY ↓ and NT ↑ ). Conclusions Activation of mononuclear cells during hemodialysis as reflected in changes of TGF- α and IGF-Ⅱ levels might be beneficial to the organism, As important internal neural transmitters, NPY and NT might participate in the pathophysiologic process of the disease and the complicated hypertension.