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多发性骨髓瘤特异性主动免疫治疗研究新进展

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摘要 多发性骨髓瘤(MM)是一种起源于浆细胞的血液系统恶性肿瘤,MM患者的免疫系统存在多种缺陷。抗肿瘤免疫治疗已证实耐受良好并且不太可能与目前的化疗药产生交叉耐药。近年来的多项临床前试验和临床试验已证实,免疫治疗有望延长MM患者生存期、改善疾病结果。笔者现就近年来MM特异性主动免疫治疗的研究新进展作一综述。
出处 《国际输血及血液学杂志》 CAS 2013年第3期251-254,共4页 International Journal of Blood Transfusion and Hematology
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  • 1Quach H, Ritchie D, Stewart AK, et al. Mechanism of action of immunomodulatory drugs ( IMiDS ) in multiple myeloma. Leukemia,2010,24(1) :22-32.
  • 2Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature, 2011,480 ( 7378) : 480-489.
  • 3Houet L, Veelken H. Active immunotherapy of multiple myeloma. Eur J Cancer,2006,42(11) :1658 -1660.
  • 4Bogen B, Malissen B, Haas W. Idiotype-specific T ceil clones that recognize syngeneic immunoglobulin fragments in the context of class Ⅱ molecules. Eur J Immunol,1986,16(11) :1373-1878.
  • 5Bogen B, Schenck K, Munthe LA, et al. Deletion of idiotype( Id)- specific T cells in multiple myeloma. Acta Oncol, 2000, a9 (7) : 783-788.
  • 6Brown RD,Pope B,Murray A,et al. Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-betal and interleukin-10. Blood, 2001, 98 (10) : 2992-2998.
  • 7Abdalla AO, Kokhaei P, Hansson L, et al. Idiotype vaccination in patients with myeloma reduced circulating myeloma eells(CMC). Ann 0ncol,2008 ,19(6) :1172-1179.
  • 8Hong S, Qian J, I,i H, et al. CpG or IFN-a are more potent adjuvants than GM-CSF to promote anti-tumor immunity following idiotype vaccine in multiple myeloma. Cancer lmmunol Immunother, 2012,61 (4) :561-571.
  • 9Hollander N. Current vaccination strategies for the treatment of B-cell lymphoma and multiple myeloma. Crit Rev ImmunoI, 2009,29(5) :399-418.
  • 10Neelapu SS, Munshi NC, Jagannath S, et al. Tumor antigen immunization of sibling stem cell transplant donors in multiple myeloma. Bone Marrow Transplant,2005,36(4) :315-323.

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