超极化^129Xe磁共振分子影像学

Magnetic Resonance Molecular Imaging with Hyperpolarized ^(129)Xe

磁共振分子影像学发展的主要瓶颈之一在于灵敏度的限制,基于激光光泵和自旋交换技术能获得增强4～5个量级的超极化129 Xe磁共振信号,因此超极化129 Xe磁共振分子影像学相对于传统MRI在灵敏度上表现出巨大的优势.围绕提高灵敏度这一核心MRI问题及其在科学研究中的应用,该文介绍了目前基于超极化129 Xe的生物分子探针的基本结构和原理,阐述了与之相关的分子影像学方法和技术,同时评述了当前的最新研究进展和发展方向.

The applications of magnetic resonance molecular imaging are often hindered by low sensitivity. Magnetic resonance signal of hyperpolarized 129Xe can be enhanced 4 5 orders of magnitude by spin-exchange optical pumping. Ultrasensitive 129 Xe magnet- ic resonance molecular imaging shows a huge advantage in sensitivity comparing with the conventional MRI. In this paper, the improvement of the sensitivity of MRI and its ap plications to scientific research are introduced; the basic structures and principle of Xe- based biosensors are interpreted; the updated methodology and technology of molecular imaging are reviewed, and the advance of magnetic resonance molecular imaging with hyperpolarized 129Xe is commented.