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LINE-1基因编码蛋白ORF-1p在肿瘤研究中的进展 被引量：1

Advances of LINE-10RF-lp in tumor research
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摘要 LINE-1基因是人类基因组的重要结构和功能组成部分,在肿瘤细胞的增殖和进展过程中发挥重要作用。LINE-1基因编码两个蛋白质:LINE-1 ORF-1p和ORF-2p,目前对于ORF-2p的研究较多,而LINE-1 ORF-1p具有其自身独特的功能。本文结合我们的工作对LINE-1 ORF-1p的功能和研究进展进行综述。
作者 张帆 冯帆 杨俊兰
机构地区 解放军总医院肿瘤中心 军事医学科学院六所
出处 《解放军医学院学报》 CAS 2013年第7期792-794,共3页 Academic Journal of Chinese PLA Medical School
基金 全军"十二五"医学科研重点项目(DWS11J074) 中国癌症基金会(XH2011-0001)~~
关键词 LINE-1 ORF-1p 功能 分子机制
分类号 R73-051 [医药卫生—肿瘤]
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  • 1Narita N, Nishio H, Kitoh Y, et al. Insertion of a 5truncated L1 element into the 3'end of exon 44 of the dystrophin gene resulted in skipping of the exon during splicing in a case of Duchenne muscular dystrophy. J Clin Invest, 1993, 91 : 1862-1867.
  • 2Bailey J A, Carrel L, Chakravarti A, et al. Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: the Lyon repeat hypothesis. Proc Natl Acad Sci USA, 2000, 97:6634-6639.
  • 3Allen E, Horvath S, Tong F, et al. High concentrations of long interspersed nuclear element sequenee distinguish monoallelically expressed genes. Proc Natl Acad Sci USA, 2003, 100:9940-9945.
  • 4Burwinkel B, Kilimann M W. Unequal homologous recombination between LINE-1 elements as a mutational mechanism in human genetic disease. J Mol Biol, 1998, 277:513-517.
  • 5Liu L, Chen X H, Huang J, et al. NSSRI promotes neuronal differentiation of mouse embryonic carcinoma P19 cells. Neuroreport, 2004, 15:823-828.
  • 6Anthony V Furanol, David D Duvernell, Stephane Boissinot. L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish. Trends in Genetics ,2004 ,20 ( 1 ) :9-14.
  • 7Xi Shi, Andrei Seluanov, Vera Gorbunova. Cell divisions are required for L1 retrotransposition. Molecular and Cellular Biology, 2007, 27(4 ) :1264-1270.
  • 8Roman-Gomez J, Jimenez-Velasco A, Agirre X, et al. Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia. Oncogene ,2005,24:7213-7223.
  • 9Goodier J L, Zhang L, Vetter M R, et al. LINE-10RF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex. Mol Cell Biol,2007,27:6469-6483.
  • 10Wichai Pornthanakasem, Narisom Kongruttanachok, Chutipa Phuangphairoj. LINE-1 methylation status of endogenous DNA double-strand breaks.. Nucleic Acids Research, 2008, 6 ( 11 ) : 36673675.

共引文献18

同被引文献30

  • 1王怀颖,张玮,石少慧,户志杰.D-半乳糖老化模型小鼠抗氧化能力的实验研究[J].军医进修学院学报,2005,26(5):397-398. 被引量：14
  • 2Brouha B,Schustak J,Badge RM. Hot L1s account for the bulk of retrotransposition in the human population[J].Proceedings of the National Academy of Sciences(USA),2003,(09):5280-5285.
  • 3Martin SL,Cruceanu M,Branciforte D. LINE-1 retrotransposition requires the nucleic acid chaperone activity of the ORF1 protein[J].Journal of Molecular Biology,2005,(03):549-561.doi:10.1016/j.jmb.2005.03.003.
  • 4Kazazian HH Jr. An estimated frequency of endogenous insertional mutations in humans[J].Nature Genetics,1999,(02):130.doi:10.1038/9638.
  • 5Miné M,Chen JM,Brivet M. A large genomic deletion in the PDHX gene caused by the retrotranspositional insertion of a full-length LINE-1 element[J].Human Mutation,2007,(02):137-142.
  • 6van den Hurk JA,Meij IC,Seleme MC. L1 retrotransposition can occur early in human embryonic development[J].Human Molecular Genetics,2007,(13):1587-1592.doi:10.1093/hmg/ddm108.
  • 7Chen JM,Masson E,Macek M. Detection of two Alu insertions in the CFTR gene[J].Journal of Cystic Fibrosis,2008,(01):37-43.
  • 8Deininger PL,Batzer MA. Alu repeats and human disease[J].Molecular Genetics and Metabolism,1999,(03):183-193.doi:10.1006/mgme.1999.2864.
  • 9Ostertag EM,Kazazian HH Jr. Biology of mammalian L1 retrotransposons[J].Annual Review of Genetics,2001.501-538.
  • 10Wallace NA,Belancio VP,Deininger PL. L1 Mobile element expression causes multiple types of toxicity[J].Gene,2008,(1-2):75-81.

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解放军医学院学报
2013年 第7期

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