氯吡格雷联合低分子肝素治疗短暂性脑缺血发作的疗效观察

The observation of the efficacy of Clopidogrel combined with Low molecular weight heparin in the treatment of transient ischemic attack

目的观察氯吡格雷联合低分子肝素治疗短暂性脑缺血发作的临床效果。方法将近年来在我院就诊的82例短暂性脑缺血发作患者分为观察组和对照组各41例,两组均采用常规方法治疗,观察组在此基础上加用氯吡格雷与低分子肝素治疗。结果观察组总有效率为90.2%,明显高于对照组65.9%的总有效率(P<0.05);治疗后,观察组患者的PT和PLT水平与治疗前比较有统计学差异(P<0.05),而且PLT水平与对照组比较亦有统计学差异(P<0.05)。结论在常规治疗的基础上加用氯吡格雷与低分子肝素治疗短暂性脑缺血发作疗效显著,用药安全,可有效控制短暂性脑缺血发作及降低血栓形成的机率。

Objective To observe the clinical effect of Clopidogrel combined with Low molecular weight heparin in the treatment of transient ischemic attack.Methods Eighty-two transient cerebral ischemic attack（TIA）patients in our hospital were divided into the observation group and the control group,and 41 cases in each group.Conventional treatments were used in both group,and additional treatment of Clopidogrel combined with Low molecular weight heparin was taken in the observation group.Results The total effective rate in the control group was 90.2%,higher than 65.9% of the control group,and there was a significant difference（P〈0.05）.The PT detection in the observation group after treatment was significantly higher than that before treatment.After treatment,PLT was significantly Lower than before treatment;there were significant differences（P〈0.05）.Conclusion Clopidogrel combined with Low molecular weight heparin based on the conventional treatment for TIA patients is safe and effective significantly,and it can effectively control TIA,reduce the probability of thrombus formation.