慢性阻塞性肺疾病急性加重期患者应用抗生素治疗的临床效果分析

The analysis of the clinical effect of antibiotics for patients with chronic obstructive pulmonary disease with acute exacerbation

目的探讨慢性阻塞性肺疾病急性加重期患者应用抗生素治疗的临床效果。方法将2011年1月至2012年8月我院收治的140例慢性阻塞性肺疾病急性加重期患者分为两组各70例,对照组予头孢哌酮或左氧氟沙星治疗,观察组予头孢哌酮与左氧氟沙星联合治疗,两组剂量相同;比较两组患者的治疗效果及不良反应。结果观察组与对照组的痊愈率和总有效率分别为80.00%和98.57%与52.86%和81.42%,观察组治疗效果明显优于对照组,差异有统计学意义(P<0.05);观察组与对照组分别有2例和3例出现恶心症状,未影响治疗。结论慢性阻塞性肺疾病急性加重期患者联合应用头孢哌酮和左氧氟沙星既有效又安全,值得推广应用。

Objective To investigate the clinical effect of antibiotics for patients with chronic obstructive pulmonary disease（COPD）with acute exacerbation.Methods One hundred forty cases of acute exacerbation of COPD were randomly divided into two groups,70 cases in the control group and 70 cases in the observation group.The patients in control group were treated with cefoperazone or levofloxacin and in the observation group were treated with cefoperazone united levofloxacin.The effects and adverse reactions in the two groups were compaied.Results The cure and efficiency rates in the observation group were 80.00% and 98.57% respectively,and 52.86% and 81.42% in the control group.It was significantly better in the observation group than that in the control group,and the obvious difference between the two groups was statistically significant（P〈0.05）.Two cases in the observation group and 3 cases in control group with nausea did not affect the treatment.Conclusion The united application of cefoperazone and levofloxacin for COPD with acute exacerbation is an effective and safe method.