摘要
目的:分析研究胸腔镜下肺癌根治术患者围术期血清癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白19片段(CY211)、表皮生长因子(EGF)及红细胞免疫功能的变化情况。方法:选取于本院采用开胸手术进行治疗的32例肺癌患者为对照组,并将同时期采用胸腔镜根治性手术进行治疗的32例患者设为观察组,然后将两组患者手术前1d与手术后3、7d的血清CEA、CA125、CY211、EGF水平和阳性率、红细胞免疫功能指标水平进行比较。结果:观察组与对照组手术后3、7d的血清CEA、CA125、CY211水平和阳性率比较,差异具有统计学意义(P>0.05);而术后均低于术前,EGF水平和阳性率均低于对照组,红细胞免疫功能指标则均明显优于对照组,差异均具有统计学意义(P<0.05)。结论:胸腔镜下肺癌根治术患者围术期血清CEA、CA125、CY211、EGF及红细胞免疫功能的变化较为明显,既达到了有效治疗疾病的目的,又降低了对机体免疫功能的不良影响。
Objective. To study the change of serum CEA, CA125, CY211, EGF and erythrocyte immune function of patients treated with thoracoscopic pulmonary carcinoma radical resection during peri- operative period. Methods. A total of 32 patients with pulmonary carcinoma and treated with open-chest operation in our hospital from April 2011 to February 2013 were selected as control group, 32 patients trea- ted with thoracoscopic radical resection at the same time as the observation group, then the levels and posi- tive rate of serum CEA,CA125,CY211,EGF and erythrocyte immune function indexes of two groups on the 1st day before the operation and on the 3rd,7th day after the operation were compared. Results：Levelsand positive rate of serum CEA, CA125, CY211 of observation group had no significant differences from control group （P〉0.05） while those indexes after the operation were all lower than those before the oper- ation,the levels and positive rate of EGF were all lower than those of control group,erythrocyte immune function indexes were all significantly better than those of control group （all P〈0.05）. Conclusions： Change of serum CEA, CA125, CY211, EGF and erythrocyte immune function of patients treated with tho- racoscopic pulmonary carcinoma radical resection during perioperative period is significant. Thoracoscopic pulmonary carcinoma radical resection can decrease side effect on the immune function.
出处
《海南医学院学报》
CAS
2013年第8期1080-1083,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210747)~~
