结直肠腺瘤摘除术后复发因素探讨

Risk factors of recurrent colorectal adenomas after resection

目的:探讨结直肠腺瘤摘除术后复发的影响因素。方法:选择行结直肠腺瘤摘除术的患者作为研究对象,分为术后复发的观察组和未复发的对照组,比较两组的一般情况及Cox-1、Cox-2的表达情况。结果:观察组饮食规律的比例明显少于对照组,年龄≥40岁、有家族史、吸烟史、酗酒史和焦虑抑郁情绪的比例以及Cox-2的mRNA和蛋白水平明显高于对照组;Cox-2含量与年龄、家族史、吸烟史、酗酒史和精神状态呈正相关,与饮食习惯呈负相关。结论:年龄、家族史、吸烟史、酗酒史、精神状态、饮食习惯等因素可能通过影响腺瘤组织局部Cox-2的表达来参与结直肠腺瘤的复发。

Objective： To study risk factors of recurrent colorectal adenomas after resection. Meth- ods： Colorectal adenoma patients were collected and divided into observation group with recurrence and control group without recurrence. Then general status and expression of Cox-I, Cox-2 were compared. Results： Less patients had regular diet compared with control group, and they were ≥40 years old in ob- servation group. More patients had family history, smoking history, drinking history and anxiety and de- pression in observation group. Cox-2 mRNA and protein levels were significantly higher than control group. Cox-2 content was positively correlated with age, family history, smoking history, drinking histo- ry and spirit, and negatively correlated with diet. Conclusions： Age, family history, smoking history, drinking history, mental state, diet may affect recurrence of colorectal adenomas by affecting the expres- sion of local Cox-2 .