血清肿瘤标志物的联合检测在胃癌诊断中的价值

Clinical value of tumor markers combined detection in diagnosis of grastric cancer

目的:探讨癌胚抗原(CEA)、癌相关糖抗原(CA19-9)血清肿瘤标志物在胃癌诊断中的价值,以提高胃癌的诊断率。方法:检测50例健康者及50例胃癌患者中的血清CEA、CA19-9的含量。结果:胃癌组2种血清肿瘤标志物含量明显高于健康对照组,差异具有统计学意义(t=13.197、9.527,P均<0.05),单个检测在胃癌中的灵敏度和特异性分别为63.2%、52.4%、73.7%、61.9%,两组肿瘤标志物联合检测的灵敏度和特异性分别为86.4%、90.0%。联合检测组灵敏度明显优于肿瘤标志物单项测定。胃癌患者血清CEA和CA19-9水平有一定的相关性(r=0.346,P<0.05)。结论:CEA和CA19-9肿瘤标志物联合检测可为胃癌的诊断提供可靠依据,建议临床工作中采用CEA+CA19-9联合检测。

Objective. To explore the clinical value of combined detection of tumor markers CEA, CA19-9 in the diagnosis of gastric cancer, so as to improve the diagnostic accuracy of gastric cancer. Meth- ods： Serum levels of CEA,CA19-9 in 50 healthy subjects （healthy control group） and 50 patients with gas- tric cancer（gastric cancer group） were measured. Results： The serum levels of CEA and CA19-9 were sig- nificantly higher in gastric cancer group than that in healthy control group （t= 13. 197% 9. 527, P〈0.05）. The sensitivity and specificity of single marker detection for CEA was 63.2% and 52.4% ,for CA19-9 it was 73.7% and 61.9%. For combined detection of the two tumor markers （CEA-t-CA19-9） sensitivity and specificity was 86.4 % and 90.0 %, respectively. The sensitivity of combined detection was superior to that of single detection. Correlation analysis showed maternal antibody titers CEA and CA19-9 levels was posi-tively correlated （r= 0. 346, provide reliable evidence for adopted in the clinical test. P〈0.05）. Conclusion.- Combined detection diagnosis of gastric cancer suggesting that of CEA CEA＋ and CA19-9 levels may CA19-9 detection can be