瑞芬太尼在老年骨折患者术后镇痛中的效果与安全性观察

Efficiency and safety of remifentanil for postoperative analgesia in elderly patients with fractures

目的:对比观察瑞芬太尼与芬太尼应用于老年骨折患者术后的镇痛效果及安全性。方法:选取在我院接受治疗的老年骨折患者70例,随机分为实验组和对照组,每组35例,实验组患者术后使用瑞芬太尼+昂丹西酮+生理盐水静脉注入镇痛,而对照组患者术后使用芬太尼+昂丹西酮+生理盐水静脉注入镇痛,对比两组患者术后不同时间截点(4、8、12、24、48h)的疼痛程度及术后不良反应发生情况。结果:实验组患者术后疼痛程度显著小于对照组(P<0.05),术后恶心、呕吐的严重程度明显轻于对照组,发生皮肤瘙痒的比例也小于对照组(P<0.05)。结论:老年骨折患者术后应用瑞芬太尼行术后镇痛效果显著,且安全性较高,值得临床推广。

Objective. To compare the efficiency and safety of remifentanil and fentanyl for postop- erative analgesia in elderly patients with fractures. Methods. Seventy elderly patients with fractures who were treated in our hospital were enrolled and randomly divided into experimental group and control group with 35 cases in each group. After undergoing operation, the experimental group was given remifentanilq- ondansetron＋normal saline for postoperative analgesia, while the control group was given fentanylq- on- dansetronq-normal saline. Severity of pain at time points including 4 h, 8 h, 12 h, 24 h, 48 h after the op- eration were compared~ side effects were observed. Results： Severity of pain, nausea and vomiting of the experimental group were significant lighter than that of the control group, incidence of skin itching of the observation group was also lower than that of the control group （P all〈0.05）. Conclusion： Remifentanil is effective and safe for postoperative analgesia in elderly patients with fractures, ifs worthy of application inlarge scale.