阿托伐他汀和贝那普利对高血压患者颈动脉内膜中层厚度和血脂水平及超敏C反应蛋白的影响

Effects of Atorvastatin and Benazepril on Carotid Intima-media Thickness,Blood Lipid Levels and High-sensitivity C-reactive Protein in Patients with Hypertension

目的观察阿托伐他汀和贝那普利对高血压患者颈动脉内膜中层厚度(IMT)、血脂水平和超敏C反应蛋白(hs-CRP)的影响。方法将114例高血压患者随机分为治疗组和对照组,各57例。治疗组给予阿托伐他汀(10mg/次,1次/d,口服),贝那普利片(5mg/次,1次/d,口服);对照组给予阿司匹林肠溶片(100mg/次,1次/d,口服),卡托普利片(12.5mg/次,3次/d,口服)。均治疗6个月,观察治疗前后血压、颈动脉IMT、血脂水平及hs-CRP的变化。结果治疗后两组收缩压、颈动脉IMT、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、血清hs-CPR比较,差异均有统计学意义(P<0.05)。结论阿托伐他汀和贝那普利能有效控制高血压患者的血压水平,调节血脂水平,改善高血压患者颈动脉IMT,抑制炎症反应,延缓颈动脉内膜的增生。

Objective To observe the effects of atorvastatin and benazepril in hypertensive patients on carotid artery intima-media thickness（IMT）,blood lipid levels and high-sensitivity C-reactive protein（hs-CRP）.Methods 114 hypertensive patients were randomly divided into a treatment group and the control group,57 cases each.The treatment group received atorvastatin（10mg/each time,1 time/day,orally）,benazepril tablets（5mg each time,1 time/day,orally）;control group was given aspirin enteric-coated tablets（100mg each time,1 time/day,orally）,captopril tablets（12.5mg each time,3time/day,orally）.6 months of treatment,observed the blood pressure,carotid IMT,lipid levels and hs-CRP changes before and after treatment.Results After treatment systolic,blood pressure,carotid IMT,total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,serum hs-CPR of two groups were compared,the differences were statistically significant（P〈0.05）.Conclusion Atorvastatin and benazepril can effectively control the level of blood pressure in hypertensive patients,regulating blood lipid.