阿托伐他汀钙联合胺碘酮治疗阵发性心房纤颤的临床疗效观察

Clinical Efficacy Observation of Atorvastatin Calcium Combined with Amiodarone in Treatment of Paroxysmal Atrial Fibrillation

目的观察阿托伐他汀钙联合胺碘酮治疗阵发性心房纤颤的临床疗效。方法选取72例阵发性心房纤颤患者,随机分为对照组和治疗组,各36例。两组患者均给予积极治疗原发病,对照组给予胺碘酮治疗,治疗组在对照组用药基础上联合应用阿托伐他汀钙。随访12个月,观察两组的疗效。结果治疗组总有效率高于对照组(92.2%与76.6%),差异有统计学意义(P<0.05)。治疗后,治疗组的左心房内径小于对照组,差异有统计学意义(P<0.05)。结论阿托伐他汀钙联合胺碘酮能缩短心房纤颤患者的左心房内径,减少心房纤颤的复发和持续性心房纤颤的发生。

Objective To observe clinical curative effect of atorvastatin calcium combined with amiodarone in treatment of paroxysmal atrial fibrillation.Methods We selected 72 cases of patients with paroxysmal atrial fibrillation,were randomly divided into the control group and the treatment group,each group with 36 cases.Two groups were treated by active treatment of the original diseases,control group treated with amiodarone therapy,the treatment group in the control group of drugs based on the combined application of atorvastatin calcium.A follow-up of 12 months,to observe the effects of two groups.Results The total effective rate of treatment group was significantly higher than that in the control group（92.2% vs.76.6%）,the difference was statistically significant（P〈0.05）.After the treatment,the treatment group of left atrial diameter significantly less than the control group,the difference was statistically significant（P〈0.05）.Conclusion Atorvastatin calcium combined with amiodarone can shorten the atrial fibrillation in patients with left atrial diameter,reduction of atrial fibrillation recurrence and persistence of atrial fibrillation.