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过氧化物酶体增殖物激活受体γ与肥胖及2型糖尿病的关系研究进展 被引量：7

The Relationship of Peroxisome Proliferators-activated Receptor Gamma with Obesity and Type 2 Diabetes Mellitus
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摘要 过氧化物酶体增殖物激活受体γ(PPAR-γ)是核转录受体家族成员,它在脂肪细胞分化、肥胖和糖尿病中都具有重要的作用。本文就PPAR-γ的结构及配体以及其与肥胖和2型糖尿病的关系做一综述。 Peroxisome proliferator - activated receptor gamma （ PPAR -γ）, a member of nuclear receptor family, plays an important role in adipocyte differentiation, obesity and diabetes. In this paper, the structure and ligand of PPAR -~/and its relationship with obesity and type 2 diabetes are briefly reviewed.
作者 郝丹丹 张凤宁 张垒 瑞云
机构地区 赤峰学院医学院
出处 《中国全科医学》 CAS CSCD 北大核心 2013年第15期1697-1701,共5页 Chinese General Practice
关键词 过氧化物酶体增殖物激活受体Γ 肥胖症 糖尿病 2型 脂细胞 Peroxisome proliferator - activated receptor gamma Obesity Diabetes mellitus, type 2 Adipocytes
分类号 R589.25 [医药卫生—内分泌] R587.1 [医药卫生—内分泌]
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  • 2Clement K, Hercberg S, Passinge B, et al. The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes. Int J Obes Relat Metab Disord 2000; 24:391-393.
  • 3Mancini FP, Vaccaro O, Sabatino L, et al. Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes. Diabetes 1999; 48:1466- 1468.
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  • 7Hamer OW, Forstner D, Ottinger I, et al. The Prol 15Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity. Exp Clin Endocrinol Diabetes 2002; 110:230-234.
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中国全科医学
2013年 第15期

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