单纯性肥胖儿童血清铁蛋白测定的临床意义

Determination of SF in Simple Obese Children and Its Clinical Significance

目的探讨血清铁蛋白(SF)测定对于单纯性肥胖儿童的临床意义。方法选取2009年1月—2011年12月在漯河医学高等专科学校第二、三附属医院门诊就诊的单纯性肥胖儿童96例,其中轻度肥胖40例,中重度肥胖56例。另选取同时期体质量正常的健康儿童90例为对照组。检测血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、SF水平,行肝脏B超查看脂肪肝发生情况。结果对照组、轻度肥胖组、中重度肥胖组TC、TG、LDL-C、SF水平比较,差异均有统计学意义(P<0.05);3组HDL-C水平比较,差异无统计学意义(P>0.05)。对照组和轻度肥胖组均无脂肪肝发生,而中重度肥胖组有13例并发脂肪肝,检出率为23.2%。根据是否发生脂肪肝分为:脂肪肝组13例和非脂肪肝组173例,脂肪肝组SF水平为(84±10)μg/L,非脂肪肝组为(31±10)μg/L,两组比较差异有统计学意义(t=2.769,P=0.003)。结论中重度单纯性肥胖儿童SF显著增高,SF测定可以作为早期发现中重度肥胖儿童脂肪肝或脂肪肝倾向的预警指标,对于中重度单纯性肥胖儿童脂肪肝的早期诊断具有重要意义。

Objective To discuss the clinical significance of SF determination in the evolution of simple obese chil- dren. Methods 96 children with simple obesity （40 cases of mild obesity and 56 cases of moderate or severe obesity） admitted to the Second and Third Affiliated Hospital of Luohe Medical College from January 2009 to December 2011 were involved into the study. 90 healthy children were selected as control group. TC, TG, LDL - C, HDL - C and SF levels were determined and liver B ultrasound was conducted to test fatty liver condition. Results TC, TG, LDL - C, and SF levels among mild obesity group, moderate or severe obesity group and control group showed statistically significant differences （ P 〈 0.05 ）, but the HDL - C levels among the three groups showed no statistically significant difference （ P 〉 0. 05 ） . No fatty liver cases were found in control group and mild obesity group, while 13 cases of fatty liver were found in moderate or severe obesity group with an detection rate of 23.2%. The patients were divided into fatty liver group （13 cases） and non -fatty liver group （173 cases）, and the SF level in the former was （84 ±10） μg/L, and in the latter was （31 ± 10）μg/L, and the difference was statistically significant （t = 2. 769, P = 0. 003 ） . Conclusion SF level was significantly higher in severe simple obese children. The determination of SF can be used as a warning indicator in the early detection of fatty liver or fatty liver tendency of those children with moderate or severe obesity. It plays an important role for the early diagnosis of fatty liver of the children with moderate or severe simple obesity.