我院32例万古霉素血药浓度监测结果与临床疗效分析

Clinical effects and blood concentration of vancomycin:32 cases report

目的评价我院32例患者万古霉素血药浓度监测结果与临床疗效分析，为临床合理用药提供参考。方法对我院2011年12月～2012年4月应用万古霉素并监测血药浓度的32例住院患者的临床资料（基础疾病、细菌学培养结果、用药情况、万古霉素血药谷浓度、疗效、肾功能情况等）进行统计、分析。结果细菌检出率53％，用药指征细菌学符合率31％。应用万古霉素的总有效率为69％，万古霉素血药浓度所测得谷值在10～20mg／L范围内者占25％，治疗后肾功能异常发生率为13％。结论32例应用万古霉素患者初次测得其血药浓度谷值在有效范围内的比例偏低，对老年患者需重视其血药浓度监测，并结合临床实际实现个体化给药。

Objective To evaluate clinical utilization and blood concentration monitoring of vancomycin in our hospital and of- fer reference to reasonable clinical use of drugs. Methods The clinical information （primary diseases, bacteriological culture, blood concentration of vancomyein, clinical efficacy, renal function） of 32 inpatients who had been treated with vancomycin and their blood concentrations from Dec. 2011 to Apr. 2012 were analyzed statistically. Results The bacteria detection rate was 53%. The drug indications bacteriology coincidence rate was 31% . The total response rate of vancomyein was 68.75% . The valley values of 25% cases were between 10 mg/L and 20 mg/L. The incidence of renal dysfunction after treatment was 12.5%. Conclusion The valley value of blood concentration of the 32 cases using vancomycin that first measured were less in effective range which should be paid attention to the blood concentration monitoring of agedness patients to achieve an ideal individual administration according to clinical practice.