可乐定治疗原发性顽固性高血压的疗效观察

Observation on clonidine on refractory essential hypertension

目的观察可乐定治疗原发性顽固性高血压的疗效及安全性。方法选择原发性顽固性高血压患者为研究对象,入选患者加服可乐定片(75μg/次,1次/8 h,1周后未达标,改为150μg/次,1次/8 h),观察治疗前及治疗后每周诊室坐位血压、心率,检测治疗前后动态血压(ABPM)、血常规、肝肾功能、电解质、血脂及尿常规。结果治疗后4周,诊室血压、ABPM的收缩压和舒张压均显著低于治疗前,差异有统计学意义(P<0.01);根据诊室坐位血压,总有效率89.4%;根据ABPM,总有效率为80.8%。治疗后可出现心率下降、口干、乏力、嗜睡、便秘等不良反应,但无需停药。结论可乐定对原发性顽固性高血压降压疗效确切,副反应可接受。同时不影响代谢,安全性好。

Objective To explore the effect of clonidine on refractory essential hypertension. Methods A total of 47 patients suffered refractory essential hypertension were included in the study, which were accepted treatment of elonidine （75 μg/8 h for 1 week, if did not reach the standard, changed to 150 μg/8 h）. The difference of the clinic blood pressure, ambulatory blood pressure monitoring （ABPM） and adverse reaction were compared before and after treatment. Results After treatment for four weeks, the clinic blood pressure and ABPM were significantly lower than that before treatment（ P 〈 0.05 ） ; the efficiency was 89.4% and 80.8% respectively, according to the clinic blood pressure and ABPM. Methods The clonidine had a good effect on refractory essential hypertension.