孕早期人细小病毒B19感染与血清hCG、hPL水平变化的关系

Relationship between first trimester parvovirus B19 infection and hCG, hPL level changes

目的探讨孕早期人细小病毒B19感染与血清人绒毛膜促性腺激素(hCG)、人胎盘生乳素(hPL)水平变化的关系。方法采用酶联免疫吸附试验(ELISA)法检测294例孕早期人工流产孕妇(其中阳性22例,阴性272例)血清中人细小病毒B19抗体IgM(HPVB19-IgM)及IgG的含量,根据血清HPVB19-IgM检测结果,将所有患者分为阳性组(22例)及阴性组(272例),采用ELISA和MIROELISA法检测其相应外周血血清中hCG、hPL水平。结果孕早期人工流产孕妇HPVB19-IgM阳性者血清中hCG为(83.19±32.69)mIU/mL,阴性组为(106.68±43.26)mIU/mL,两组比较,P<0.05;阳性组血清中hPL为(51.06±40.63)ng/mL,阴性组为(75.49±53.17)ng/mL,两组比较,P<0.05。结论孕早期人细小病毒B19感染可减少hCG、hPL的分泌量,这可能是孕早期HPVB19感染引起不良妊娠结局的生殖内分泌基础。

Objective To investigate the relationship between first trimester parvovirus B19 infection and the level of human chorionic gonadotropin （hCG） and human placental lactogen （hPL）. Methods The contents of HPVB19-IgM and IgG in 294 patients with early pregnancy abortion （22 cases were positive, 272 cases were negative ） were detected by ELISA method. According to the detection of serum HPVB19-IgM, all patients were divided into the positive group （22 cases） and the negative group （272 cases）. The hCG and hPL levels in the corresponding peripheral blood were detected by the ELISA and MIROELISA method. Results The blood serum hCG level in the positive group was （83.19 ± 32.69） mlU/mL, and the negative group was （106.68 ± 43.26） mlU/mL; the difference was statistically significant （P 〈 0.05）. The hPL level in the positive group was 51.06 ± 40.63 ng/mL and the negative group was 75.49 ±53.17 ng/mL; the difference was statistically significant （ P 〈 0.05 ）. Conclusion The first trimester human parvovirus B19 infection can reduce the secretion of hCG and hPL. This can be the reproductive endocrine basis of the first trimester HPVB19 infection induced adverse pregnancy outcomes.