CagA^+幽门螺杆菌根除前后对胃溃疡患者血清基质金属蛋白酶-9及hsCRP的影响

Effect of CagA^+ Helicobacter pylori eradication on the levels of serum hsCRP and matrix metalloproteinase-9 in patients with gastric ulcer

目的:探讨细胞毒素相关基因A+(CagA+)幽门螺杆菌(Hp)根除前后对胃溃疡患者血清基质金属蛋白酶-9(MMP-9)及高敏CRP(hsCRP)的影响。方法:55例Hp+CagA+胃溃疡患者为根除治疗组,同期就诊的55例Hp-CagA-胃溃疡患者为对照组,根除治疗组患者研究开始时根除Hp治疗采用三联疗法,包括阿莫西林(1 g,2次/日)、克拉霉素(500 mg,2次/日)及埃索美拉唑(20 mg,1次/日),疗程7 d。随访3个月,研究前后同时检测两组患者血清hsCRP及MMP-9。结果:研究开始时,根除治疗组血清胆固醇、hsCRP及MMP-9水平比对照组高(P<0.05);研究结束时,两组血清胆固醇、hsCRP及MMP-9水平比较差异无统计学意义(P>0.05);与研究前比较,根除治疗组研究结束时血清胆固醇、hsCRP及MMP-9水平明显降低(P<0.05)。结论:通过根除Hp+CagA+,可降低胃溃疡患者血清hsCRP及MMP-9水平,降低患者的炎症损伤,因此可促进溃疡愈合。

Objective： To investigate the effect of cytotoxin associated gene A ＋ （CagA ＋ ） Helicobacter pylori （Hp） eradication on the levels of serum high sensitive C reactive protein （hsCRP） and matrix metalloproteinase-9 in patients with gastric ulcer. Methods： A total of 55 patients with gastric ulcer and CagA ＋ Hp （eradication group） and 55 patients with gastric ulcer and without Hp （control group） were recruited in this study. At the be- ginning of study, the patients in eradication therapy group were adminstrated with eradication therapy for a week to Hp. However, the patients in control group were adminstrated with placebo for a week on the basis of general treat- ment. The levels of serum hsCRP and matrix metalloproteinase-9 （MMP-9） were performed at the beginning and the end of study in all subjects. The follow-up period was 3 months. Results： In comparison with control group, the levels of serum total cholesterol, hsCRP and MMP-9 were significantly increased in erdication group at enroll- ment. However there were no significant differences between the two groups in these parameters at the end of this study. In comparison with the levels before eradication, the levels of serum total cholesterol, were tion tion significantly decreased in erdication group at the end of study, P 〈 0. 05. Conclusions： might improve the levels of serum total cholesterol, hsCRP and MMP-9, and decrease the and encourage the healing of ulcer in patients with gastric ulcer and Hp ＋CagA ＋. hsCRP and MMP-9 Hp ＋ CagA ＋ eradica- injuries of inflamma-