摘要
1例73岁男性因急性脑梗死合并癫痫、高血压、支气管炎、冠状动脉粥样硬化性心脏病、心房颤动入院,先后给予甘露醇、甘油果糖,缬沙坦、富马酸比索洛尔、马来酸桂哌齐特、奥扎格雷钠、哌拉西林钠他唑巴坦钠、头孢他啶、依替米星、阿托伐他汀钙。用药前丙氨酸转氨酶(ALT)18 U/L,天冬氨酸转氨酶(AST)25 U/L。第13天,ALT 243 U/L,AST 111 U/L。停用马来酸桂哌齐特并给予葡醛内酯、谷胱甘肽。停用马来酸桂哌齐特第7天,ALT36 U/L,AST 27 U/L。
A 73-year-old man was hospitalized for acute cerebral infarction accompanied by epilepsy, hypertension, bronchitis, coronary atherosclerotic heart disease, and atrial fibrillation. He received mannitol, glycerol and fructose, valsartan, bisoprolol fumarate, cinepazide maleate, ozagrel sodium, piperacillin sodium and tazobactam sodium, ceftazidime, etimicin, and atorvastatin calcium. Laboratory tests before treatment showed the following levels： alanine aminotransferase （ALT） 18 U/L, aspartate aminotransferase （AST） 25 U/L. On day 13, his ALT and AST levels increased to 243 U/L and 111 U/L. Cinepazide maleate was stopped. Glucurolactone and glutathione were given. On day 7 of cinepazide maleate withdrawal, his ALT and AST levels decreased to 36 U/L and 27 U/L, respectively.
出处
《药物不良反应杂志》
CSCD
2013年第2期108-109,共2页
Adverse Drug Reactions Journal
关键词
桂哌齐特
药物性肝损伤
Cinepazide
Drug induced liver injuty
