摘要
目的探讨血小板计数、纤维蛋白原、D-二聚体检测对于宫颈癌患者的临床意义。方法检测87例宫颈癌患者(宫颈癌组)及66例宫颈良性病变患者(对照组)的血小板计数、纤维蛋白原、D-二聚体水平,分析三者的临床意义。结果宫颈癌组患者血小板计数、纤维蛋白原及D-二聚体均明显高于对照组[(274.22±82.32)×10^9/L比(238.82±74.97)×10^9/L、(3.03±0.59)玑比(2.67±0.45)g/L、(182.77±167.07)ng/L比(113.74±64.84)ng/L],差异均有统计学意义(P〈0.05)。国际妇产科协会分期Ⅱ期患者较Ⅰ期患者、肿瘤直径〉4cm患者较≤4cm患者血小板计数、纤维蛋白原、D-二聚体均明显升高[(296.66±94.30)×10^9/L比(251.26±60.86)×10^9/L、(3.22±0.67)g/L比(2.84±0.42)g/L、(238.61±213.29)ng/L比(125.63±62.96)ng/L,(299.14±81.33)×10^9/L比(257.44±79.39)×10^9/L、(3.20±0.67)g/L比(2.91±0.50)g/L、(281.29±223.33)ng/L比(116.46±51.69)ng/L],差异均有统计学意义(P〈0.05)。淋巴结转移阳性患者与阴性患者各指标比较差异均无统计学意义(P〉O.05)。结论宫颈癌患者血小板计数、纤维蛋白原、D-二聚体检测有助于宫颈癌的诊断、治疗及预后的判定。
Objective To study the clinical value of the platelet count (PC),fibrinogen (Fib) and D-dimer detection in patients with cervical cancer. Methods Eighty-seven patients with cervical cancer ( cervical cancer group ) and 66 patients with cervical benign lesion (control group ) were selected, the levels of PC, Fib and D-dimer were respectively determined to analyze the clinical significance of three factors. Results The PC,Fib and D-dimer in cervical cancer group were significantly higher than those in control group [ (274.22 ± 82.32) x 10^9/L vs. (238.82± 74.97) x 10^9/L, (3.03 ±0.59) g/L vs. (2.67 ± 0.45) g/L, ( 182.77 ± 167.07 ) ng/L vs. ( 113.74 +±64.84) ng/L, P 〈 0.05 ]. Patients with stage II and tumor volume 〉 4 cm were obviously higher than patients with stage I and tumor volume ≤4 cm in the PC, Fib and D-dimer [(296.66 ±94.30) x 10^9/L vs. (251.26 ±60.86) x 10^9/L, (3.22 ±0.67) g/L vs. (2.84 ±0.42) g/L, (238.61 ±213.29) ng/L vs. (125.63±62.96) ng/L, (299.14±81.33) x 10^9/L vs. (257.44 ±79.39) x 10^9/L,(3.20±0.67) g/L vs. (2.91 ±0.50) g/L,(281.29 ±223.33) ng/Lvs. (116.46±51.69) ng/L,P〈 0.05 ]. But there was no significant difference between lymph node metastasis positive patients and lymph node metastasis negative patients (P 〉 0.05). Conclusion The PC,Fib and D-dimer of patients with cervical cancer are helpful to clinical cervical cancer diagnosis, treatment and prognosis improvement.
出处
《中国医师进修杂志》
2013年第15期12-14,共3页
Chinese Journal of Postgraduates of Medicine
关键词
宫颈肿瘤
血小板计数
纤维蛋白原
Uterine cervical neoplasms
Platelet count
Fibrinogen