宫颈癌患者血小板计数、纤维蛋白原、D-二聚体检测的临床意义

Clinical significance of platelet count,fibrinogen and D-dimer detection in patients with cervical cancer

目的探讨血小板计数、纤维蛋白原、D-二聚体检测对于宫颈癌患者的临床意义。方法检测87例宫颈癌患者（宫颈癌组）及66例宫颈良性病变患者（对照组）的血小板计数、纤维蛋白原、D-二聚体水平，分析三者的临床意义。结果宫颈癌组患者血小板计数、纤维蛋白原及D-二聚体均明显高于对照组[（274．22±82．32）×10^9／L比（238．82±74．97）×10^9／L、（3．03±0．59）玑比（2．67±0．45）g／L、（182．77±167．07）ng／L比（113．74±64．84）ng／L]，差异均有统计学意义（P〈0．05）。国际妇产科协会分期Ⅱ期患者较Ⅰ期患者、肿瘤直径〉4cm患者较≤4cm患者血小板计数、纤维蛋白原、D-二聚体均明显升高[（296．66±94．30）×10^9／L比（251．26±60．86）×10^9/L、（3．22±0．67）g/L比（2．84±0．42）g／L、（238．61±213．29）ng／L比（125．63±62．96）ng／L，（299．14±81．33）×10^9／L比（257．44±79．39）×10^9／L、（3．20±0．67）g／L比（2．91±0．50）g／L、（281．29±223．33）ng／L比（116．46±51．69）ng／L]，差异均有统计学意义（P〈0．05）。淋巴结转移阳性患者与阴性患者各指标比较差异均无统计学意义（P〉O．05）。结论宫颈癌患者血小板计数、纤维蛋白原、D-二聚体检测有助于宫颈癌的诊断、治疗及预后的判定。

Objective To study the clinical value of the platelet count （PC）,fibrinogen （Fib） and D-dimer detection in patients with cervical cancer. Methods Eighty-seven patients with cervical cancer （ cervical cancer group ） and 66 patients with cervical benign lesion （control group ） were selected, the levels of PC, Fib and D-dimer were respectively determined to analyze the clinical significance of three factors. Results The PC,Fib and D-dimer in cervical cancer group were significantly higher than those in control group [ （274.22 ± 82.32） x 10^9/L vs. （238.82± 74.97） x 10^9/L, （3.03 ±0.59） g/L vs. （2.67 ± 0.45） g/L, （ 182.77 ± 167.07 ） ng/L vs. （ 113.74 ＋±64.84） ng/L, P 〈 0.05 ]. Patients with stage II and tumor volume 〉 4 cm were obviously higher than patients with stage I and tumor volume ≤4 cm in the PC, Fib and D-dimer [（296.66 ±94.30） x 10^9/L vs. （251.26 ±60.86） x 10^9/L, （3.22 ±0.67） g/L vs. （2.84 ±0.42） g/L, （238.61 ±213.29） ng/L vs. （125.63±62.96） ng/L, （299.14±81.33） x 10^9/L vs. （257.44 ±79.39） x 10^9/L,（3.20±0.67） g/L vs. （2.91 ±0.50） g/L,（281.29 ±223.33） ng/Lvs. （116.46±51.69） ng/L,P〈 0.05 ]. But there was no significant difference between lymph node metastasis positive patients and lymph node metastasis negative patients （P 〉 0.05）. Conclusion The PC,Fib and D-dimer of patients with cervical cancer are helpful to clinical cervical cancer diagnosis, treatment and prognosis improvement.