鼠神经生长因子治疗带状疱疹的临床研究

Clinical study for mouse nerve growth factor on treating herpes zoster

目的观察鼠神经生长因子（mNGF）治疗带状疱疹的临床疗效。方法将64例带状疱疹患者，按随机数字表法分为治疗组和对照组，每组32例，两组均给予常规治疗，治疗组在常规治疗的基础上应用mNGF肌肉注射，每日30μg，共14d，每5d观察疼痛变化情况，共观察1个月。结果治疗组疼痛减轻时间、疼痛消失时间分别为（4．36±2．01）、（12．29±1．98）d，均短于对照组的（7．23±3．57）、（20．36±2．24）d，差异有统计学意义（t=5．21、8．37，P〈0．01）；治疗组总有效率为96．9％（31／32），显著高于对照组的71．9％（23／32），差异有统计学意义（P〈0．05）。结论mNGF配合常规治疗能明显缩短带状疱疹受累神经的修复过程，改善临床症状，并且不良反应少。

Objective To observe the effect of mouse nerve growth factor （mNGF） on treating herpes zoster. Methods The 64 patients with herpes zoster were divided into treatment group and control group by random digits table with 32 cases each. The control group received only routine treatment,the treatment group based on routine treatment combined with mNGF 30 μg, both groups were treated 14 days. Pain changes of two groups were observed in once every 5 days,a total of 1 month. Results The times of pain to lessen and the pain to vanish of treatment group were （4.36 ± 2.01 ） and （ 12.29 ± 1.98 ） d, those of control group were （7.23 ± 3.57） and （20.36 ± 2.24） d,there were significant differences （t = 5.21 and 8.37,P 〈 0.01 ）. The effective rate of treatment group was significantly higher than that of control group [96.9%（31/32） vs. 71.9%（23/32）,P〈0.05]. Conclusion mNGF combined with routine treatment can significantly shorten the course of nerve injury and improve the prognosis with few adverse reactions.