推拿手法治疗早期2型糖尿病的临床观察研究

Clinical study of manipulation in the treatment of early type 2 diabetes mellitus

目的比较推拿联合药物对早期2型糖尿病的影响,探讨推拿手法的作用机制。方法用前瞻性研究方法,将120例早期2型糖尿病患者分为治疗组和对照组,每组各60例。治疗前、治疗后第4周分别检测空腹血糖(FPG)、腰围、体重指数(BMI)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、胰岛素(FINS)水平、胰岛素抵抗指数(HOMA-IR),评价两组临床疗效。结果治疗组临床总有效率为92.8%,对照组临床总有效率为75.7%,两组比较差异有统计学意义(P<0.05)。治疗组患者治疗后[FPG(6.16±0.56)mmol/L]、腰围[(91.43±8.01)cm]、BMI[(25.53±1.23)kg/m2]、2 h PG[(8.26±1.97)mmol/L]、HbA1c[(6.05±0.89)%]、TG[(2.52±0.78)mmol/L]、TC[(5.32±0.71)mmol/L]、FINS[(14.59±3.67)mIU/L]、HOMA-IR(4.83±2.03)与治疗前比较数值降低,差异有高度统计学意义(P<0.01),与对照组治疗后比较差异有统计学意义(P<0.01)。结论推拿手法联合药物治疗早期2型糖尿病效果显著,可能与调节脂类代谢异常、减少胰岛素抵抗有关,值得临床推广使用。

Objective To compare the Clinical effect of massage Combined with drug treatment group （treatment group） and the drug group （control group） for early type 2 diabetes mellitus and to explore the mechanism of massage. Methods With the prospective study method, 120 Patients were divided into two groups, 60 Patients in treatment group with massage combined with drug treatment and 60 Patients in control group with drug treatment, fasting plasma glucose （FPG）, measuring waist circumference, calculation of body mass index （BMI）, 2 h postprandial blood glucose （2 h PG）, glycosylated hemoglobin （HbAlc）, triglycerides （TG） total cholesterol （TC）, insulin （FINS） levels, insulin resis- tance index （HOMA-IR）, evaluation of the clinical efficacy before treatment and after treatment 4 weeks were evalu- aated. Results The total effective rate of treatment group was 92.8% and the control group was 75.7%, and the effect of two groups were statistically significant （P 〈 0.05）. When after treatment compared with before treatment, FPG [（6.16±0.56）mmol/L], waist circumference [（91.43±8.01）cm], BMI （25.53±1.23）kg/㎡], 2 h PG [（8.26±1.97） mmol/L], HbA1c [（6.05±0.89）%], TG （2.52±0.78）mmol/L], TC [（5.32±0.71）mmol/L], FINS [（14.59±3.67） mlU/L], HOMA-IR （4.83±2.03） in the treatment group patients were lower values, and the difference was statistically significant （P 〈 0.01）, and the difference between the two groups was statistically significant （P 〈 0.01）. Conclusion The massage techniques combined with drug treatment for early type 2 diabetes mellitus have significant effect, and may regulate lipid metabolism abnor- malities, reduce insulin resistance, which is worthy of clinical use.