高压氧与盐酸多奈哌齐联合干预轻度血管性认知障碍的疗效研究

Efficacy studies of hyperbaric oxygen and donepezil hydrochloride joint intervention for mild vascular cognitive impairment

目的探讨轻度血管认知障碍患者采用高压氧及盐酸多奈哌齐联合治疗的临床效果。方法选择2011年7月～2012年8月期间来我院神经内科就诊的轻度血管性认知障碍患者180例,按治疗的方法分为4组,每组45例患者,其中Ⅰ组采用高压氧进行治疗,Ⅱ组采用盐酸多奈哌齐进行治疗,Ⅲ组采用高压氧联合盐酸多奈哌齐进行治疗,Ⅳ组采用银杏叶进行治疗。对治疗前后四组患者MOCA评分及治疗前后MOCA评分的差值进行比较。结果治疗后Ⅰ、Ⅱ、Ⅲ、Ⅳ组四组患者的MOCA评分与治疗前比较均明显升高(P<0.05)。Ⅲ组患者的MOCA的评分差值明显高于Ⅰ、Ⅱ、Ⅳ组患者(P<0.05);Ⅰ、Ⅱ组患者的MOCA的评分差值明显高于Ⅳ组(P<0.05);Ⅱ组患者的MOCA的评分差值稍微高于Ⅰ组,两组间不具有显著性差异(P>0.05)。结论轻度血管认知障碍患者采用高压氧及盐酸多奈哌齐联合治疗后能够使患者的症状得到显著的改善及延缓。

Objective To explore the clinical effects with hyperbaric oxygen and hydrochloric donepezil combination therapy. For mild vascular cognitive impairment. Methods A total of 180 cases with mild vascular cognitive impair- ment were selected in our hospital from July 2011 to August 2012 and divided into four groups,each group had 45 cases,group I were treated with hyperbaric oxygen treatment, group H were treated with donepezil hydrochloride treatment, group ]][ were treated with hyperbaric oxygen combined with donepezil hydrochloride, group IV were treated with ginkgo biloba treatment. We compared MOCA ratings of the four groups of patients before and after treatment and before and after treatment MOCA score difference. Results Compared with before treatment MOCA score in the After treatment, I, I1, Ill, 1V group were significantly higher, and there were significant differences （P 〈 0.05）. Group Ul patients MOCA score difference was significantly higher than I, II and IV patients （P 〈 0.05）; group I, 11 patients MOCA core difference was significantly higher than that of the group IV （P 〈 0.05）; group lI patients MOCA score difference was slightly higher than the group I, there were not have significant difference between the two groups （P 〉 0.05）. Conclusion Mild vascular cognitive impairment in patients with hyperbaric oxygen and hydrochloric acid donepezil combination therapy to the patient＇s symptoms are significantly improved and delay.