地佐辛与小剂量瑞芬太尼抑制全麻拔管期间心血管反应的研究

Remifentanil and Dezocine on attenuate the responses to tracheal extubation: A comparative study

目的比较瑞芬太尼与地佐辛抑制全身麻醉患者苏醒期拔管反应的效果。方法随机选择90例接受鼻中隔矫正术患者,接受全身麻醉,采用相同的麻醉给药方案。术毕麻醉苏醒期地佐辛组与对照组停止输注异丙酚及瑞芬太尼,地佐辛组患者填塞鼻腔时给予地佐辛5 mg;而瑞芬太尼组停用异丙酚后,继续输注瑞芬太尼0.05μg/(kg.min)直至气管拔管。结果三组患者的苏醒时间、拔管时间无显著差异。与对照组相比,瑞芬太尼组与地佐辛组血流动力学指标更稳定,咳嗽、不自主体动显著减少。结论瑞芬太尼与地佐辛均可有效抑制鼻部手术患者麻醉苏醒期拔管反应,减少患者血流动力学的波动,同时并不延长患者苏醒及拔管时间。

Objective To explore the effect of Remifentanil and Dezocine on attenuate the responses to tracheal extu- bation. Methods A total of 90 patients undergoing nasal operation surgery were randomly allocated into 3 groups of 30 patients each.During the emergence phase ,the remifentanil group received remifentanil at the rate of 0.05 p^g/（kg＂ min） by intravenous continuous infusion,and was ended at the time of extubation. The dezocine groups received dezocine with a dose of 5 mg by intravenous at the time of survey. Results Times to awakening and tracheal extubation were similar in 3 group. During emergence, the remifentanil group and dezocine group had a sinnificantly lower incidence and less severe coughing comperd with the control group, as well as a lower incidence of nopurposeful. Conclusion Dezocine and low-dose remifentanil attenuate the responses to tracheal extubation.