布地奈德联合沙丁胺醇雾化吸入治疗毛细支气管炎75例疗效观察

Inhaled budesonide combined with salbutamol in treatment of capillary bronchiolitis:curative effect observation of 75 cases

目的探讨布地奈德联合沙丁胺醇雾化吸入治疗毛细支气管炎的临床疗效。方法 150例毛细支气管炎患儿根据治疗方法不同分为A组和B组各75例。两组均给予抗感染、止咳、祛痰等常规治疗,其中A组在此基础上予以布地奈德混悬液(普米克令舒)0.5～1 mg,沙丁胺醇雾化溶液(万托林)0.03 mL/kg,加入0.9%氯化钠注射液至2 mL,经空气压缩泵雾化吸入,每次5～10 min,(2～3)次/d。连续用药5～7 d。分别对两组患儿治疗后的疗效及临床症状、体征消失时间进行比较和分析。结果 A组和B组患儿的显效率分别为56.0%、37.3%,有效率分别为37.3%、37.3%,总有效率分别为93.3%、74.7%,两组疗效比较差异有统计学意义(P<0.05),A组用药后的疗效明显优于B组,两组患儿的临床症状、体征消失时间对比显示,差异有统计学意义(P<0.05),A组患儿的临床症状、体征消失时间均明显快于B组。结论布地奈德联合沙丁胺醇雾化吸入治疗毛细支气管炎疗效确切、安全性好,能明显缓解患儿的喘憋、咳嗽等症状,适于基层医院推广和应用。

Objective To investigate the clinical effect of budesonide and salbutamol inhalation on bronchiolitis. Methods From November 2011 to November 2012, 150 cases of children with bronchiolitis cases will be selected as the research object, according to the different treatment methods were divided into A group and B group with 75 cases in each group. The two groups were given anti-infection, cough, phlegm and other conventional treatment, A group based on the given budesonide （Pulmicort） 0.5-1 mg, salbutamol （Ventolin） 0.03 mL/kg, adding 0.9% sodium chloride injection to 2 mL, after the air compression pump inhalation, every time 5-10 min, 2-3 per day for 5-7 days. On two groups of children after treatment of clinical symptoms and signs disappeared time, compare and analysis. Results The rate of A group and B group were 56%, 37.3%, 37.3%, 37.3% respectively. The total effective rate were 93.3%, 74.7%, compared the efficacy of the two groups were statistically significant （P 〈 0.05）, A group after treatment was significantly superior to group B, Clinical symptoms and signs, two groups of children with vanishing time comparison shows, the difference was statistically significant （P 〈 0.05）, clinical symptoms and signs disappeared time, group A patients were significantly faster than that of B group. Conclusion Inhaled budesonide combined with salbutamol in treatment of capillary bronchitis curative effect exactly, good safety, can alleviate the children with wheeze, cough and other symptoms, and is suitable for promotion and application of primary hospital.