进口与国产依托咪酯用于全麻诱导的临床比较

The Clinical Comparison of Import and Domestic Etomidate for Induction Anesthesia

目的比较进口、国产两种依托咪酯乳剂在全麻诱导时对血流动力学及麻醉深度的影响。方法选择择期手术患者40例,交替随机分为两组:Ⅰ组为进口依托咪酯组(n=20),Ⅱ组为国产依托咪酯组(n=20)。用依托咪酯0.3mg/kg全麻诱导,监测HR、平均动脉压(MBP)和脑电双频指数(BIS),同时观测睫毛反射,记录诱导前及诱导后患者的HR、MBP、BIS最低值以及达到BIS最低值的时间及自然闭眼时间、眼睑反射消失时间。结果两组依托咪酯在全麻诱导时对患者血流动力学和麻醉深度的影响无明显区别。结论进口和国产依托咪酯在全麻诱导中具有等相同药效;对血液动力学的影响无显著差别。

Objective Comparison of import, domestic two kinds of etomidate emulsion during general anesthesia induction on hemodynamics and the effect of anesthetic depth. Methods Selective operation patients in 40 cases, alternately were randomly divided into two groups： group I for the import of etomidate group （n=20）, group II （n=20） for domestic etomidate group. 0.3mg. kg-1 during induction of anesthesia with etomidate, monitoring of HR, mean arterial pressure （MBP） and bispectral index （BIS）, at the same time observation of eyelash reflex, recorded before induction and after induction with HR, MBP, BIS minimum value and reached the lowest value of BIS time and natural closed time, eyelid reflex time. Results There was no significant difference between these two kinds of etomidate about their effects on hemodynamics and depth of anesthesia during induction of general anesthesia. Conclusion Import and domestic etomidate in induction of anesthesia with the same effect; hemodynamic effect of no significant difference.