中西医结合治疗幽门螺杆菌相关性消化性溃疡78例疗效观察

Treating 78 cases of Helicobacter pylori-associated peptic ulcer in the integrative medicine

目的:观察清幽愈疡汤配合奥美拉唑、阿莫西林、克拉霉素治疗幽门螺杆菌(Hp)相关性消化性溃疡的临床疗效。方法:将156例患者随机分为两组各78例。对照组采用口服奥美拉唑、阿莫西林、克拉霉素治疗;治疗组在对照组治疗基础上加服中药自拟清幽愈疡汤(党参、柴胡、枳壳、白芍、丹参、香附、蒲公英、黄连、海螵蛸、白芨、田七粉、甘草)治疗。两组均以6周为总疗程。观察证候疗效、胃镜疗效、Hp根除率、复发率。结果:证候疗效临床痊愈率治疗组为80.77%,对照组为70.51%,总有效率治疗组为98.72%,对照组为88.46%,两组总有效率比较,差异有显著性意义(P<0.05)。胃镜疗效临床痊愈率治疗组为78.21%,对照组为66.67%,总有效率治疗组为97.44%,对照组为87.18%,两组总有效率比较,差异有显著性意义(P<0.05)。Hp根除率治疗组为93.59%,对照组为80.77%,两组比较,差异有显著性意义(P<0.05)。2年后复发率治疗组为11.48%,对照组为34.62%,两组比较差异有非常显著性意义(P<0.01)。结论:清幽愈疡汤配合奥美拉唑、阿莫西林、克拉霉素治疗幽门螺杆菌相关性消化性溃疡疗效显著。

Objective： To investigate clinical efficacy of the Qingyou Yuyang decoction plus omeprazole, amoxicillin and clarithromycin in treating Hp peptic ulcer. Methods： 156 patients were randomly divided into 2 groups, in the control omeprazole, amoxicillin and clarithromycin were given, in the treated group the Qingyou Yuyang decoction was given more. After 6 weeks syndromes, endoscopy efficacy, Hp eradication rate, recurrence rate were recorded and compared. Results： Curing rate in the treated group was 80.77%, 70.51% in the control group, the total efficiency was 98.72%/88.46%, significant difference （P〈0.05）. Gastroscopy efficiency was 78.21%/66.67%, the total efflcyency was 97.44%/87.18%, significant difference （P〈g.05）. Hp eradication rate vsas 93.59%/g0.77~/~, significant difference （P〈0.05）. 2 years recurrence rate was 11.48%/34.62%, significant difference （P〈0.01）. Conclusion： The Qingyou Yuyang decoction was effective on treating Hp peptic ulcer.