中西医结合治疗冠心病合并无症状高尿酸血症的临床研究

CLINICAL STUDY ON CORONARY HEART DISEASE WITH ASYMPOTOMATIC HYPERURICEMIA TREATED WITH INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE

目的:观察中西医结合治疗冠心病合并无症状高尿酸血症的临床疗效及其对血脂水平的影响。方法:140例冠心病合并高尿酸血症患者随机分为两组,对照组在冠心病常规治疗基础上加服苯溴马隆,观察组在冠心病常规治疗基础上加服中药汤剂,连续用药4周后评定疗效;同时测定治疗前后血尿酸含量(尿酸酶过氧化物偶联法)和血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、载脂蛋白A1(APOA1)及载脂蛋白B(APOB)水平,计算APOA1/APOB比值。结果:观察组临床疗效明显优于对照组(P<0.05);两组血尿酸浓度均明显下降,与治疗前比较具有明显差异(P<0.05),两组间比较无明显差异(P>0.05);两组血脂水平均有明显改善,观察组效果优于对照组(P<0.05)。结论:中西医结合治疗冠心病合并高尿酸血症疗效确切,降低血尿酸同时可增强冠心病的治疗效果。

Objective: To observe the curative effect of coronary heart disease with asympotomatic hyperuricemia treated with integrated traditional Chinese and western medicine and influence on blood lipid level. Methods: 140 cases of coronary heart disease with asympotomatic hyperuricemia were randomly divided into two groups,control group was given benzbromarone on the basis of conventional therapy on coronary heart disease,observing group was given Chinese herbs decoction on the basis of conventional therapy on coronary heart disease,two groups were treated for 4 weeks,than evaluating the curative effect,meanwhile determining blood uric acid by uricase peroxidase coupling method and blood total cholesterol,glycerin trilaurate,high density lipoprotein,low lipoprotein and apolipoprotein A1 and B levels,counting the ratio of APOA1/APOB. Results: The curative effect of observing group was better than that of control(P<0.05) ,the total effective rate was 97.1% . Blood uric acid concentration of the two groups was lowered obviously,there was significant difference between before and after treatment(P<0.05) ,there was no significant difference between the two groups(P>0.05) . Blood lipid level of the two groups was obviously improved,the effect of observing group was better than those in control group(P<0.05) . Results: Integrated traditional Chinese and western medicine therapy can effectively treat coronary heart disease with asympotomatic hyperuricemia,reduce blood uric acid,meanwhile improve the curative effect of coronary heart disease.